Brain Imaging Plus Urodynamics to Investigate the Brain's Control of the Bladder (NIRS/fBFB)
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Ages Eligible for Study:
60 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
women over 60 years
ambulatory women over age 60, who are incontinent at least five times weekly for 3 months despite correction of potentially reversible causes.
urinary incontinence (urge or predominantly urge) by clinical criteria.
able to accurately complete a voiding diary, to perform a 24-hour pad test under direction.
significant mental impairment [mini mental status exam (MMSE) ≤ 20)
history of bladder cancer
spinal cord lesions
artificial sphincter implant
expected to have changes in medications/doses during the trial
Patients with factors that could cause transient UI [e.g., current urinary tract infection (UTI), acute confusion] will be treated in concert with the subject's primary care provider and considered for enrollment if their UI persists.
conditions that require endocarditis prophylaxis (such as heart valve problems or bacterial endocarditis)