The Importance of GLP-1 in Post RYGB Improvement in Glycaemic Control Type 2 Diabetic Subjects
Recruitment status was Recruiting
After Roux-en-Y gastric bypass (RYGB) meal induced GLP-1 secretion is dramatically increased, while beta-cell function is increased in type 2 diabetic (T2D) subjects. The aim of this study is to establish causality between the two observations. By meal testing 10 T2D subjects with infusion of saline or exendin (9-39), a GLP-1R specific blocker, before and 1 week and 3 months after RYGB we hope to demonstrate the role of GLP-1 in improveing beta-cell function and maintaing glucose tolerance after RYGB in T2D subjects.
|Study Design:||Intervention Model: Single Group Assignment
Masking: Single Blind (Subject)
Primary Purpose: Basic Science
- Beta cell glucose sensibility in response to a meal [ Time Frame: 3 mo ] [ Designated as safety issue: No ]1 week and 3 months after RYGB with and without GLP-1R blockade.
- Glucose tolerance measured as AUC glucose afer a meal [ Time Frame: 3 mo ] [ Designated as safety issue: No ]
|Study Start Date:||April 2012|
|Estimated Primary Completion Date:||November 2012 (Final data collection date for primary outcome measure)|
Subjects undergo RYGB.
Other: Exendin 9-39 (Bachem, Germany)
On two separate experimental days before, 1 wk, and 3 mo after RYGB, subjects are given a liquid meal test during Exendin 9-39 (900 pmol/min/kg)or saline infusion. The order of the infusions is randomized.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01579981
|Contact: Nils B Jørgensen, MD||+45 firstname.lastname@example.org|
|Dept. of Endocrinology, Hvidovre Hospital||Recruiting|
|Hvidovre, Denmark, DK-2650|
|Contact: Nils B Jørgensen, MD +45 38623032 email@example.com|
|Principal Investigator: Nils B Jørgensen, MD|
|Study Chair:||Sten Madsbad, MD, DMSc||Dept. of Endocrinology, Hvidovre Hospital, Hvidovre, Denmark|
|Principal Investigator:||Nils B Jørgensen, MD||Dept. of Endocrinology, Hvidovre Hospital, Hvidovre, Denmark|