The Anesthetic Efficacy of 3% Mepivacaine Plus 2% Lidocaine With 1:100,000 Epinephrine for Lower Jaw Dental Injections
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|ClinicalTrials.gov Identifier: NCT01574807|
Recruitment Status : Completed
First Posted : April 10, 2012
Last Update Posted : July 10, 2013
|Condition or disease||Intervention/treatment||Phase|
|Pain||Drug: 3% mepivacaine/2% lidocaine with 1:100,000 epinephrine combo||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||100 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||Double (Participant, Investigator)|
|Official Title:||A Prospective, Randomized, Double-blind Study of the Anesthetic Efficacy of 3% Mepivacaine Plus 2% Lidocaine With 1:100,000 Epinephrine for Inferior Alveolar Nerve Blocks.|
|Study Start Date :||May 2012|
|Primary Completion Date :||May 2013|
|Study Completion Date :||May 2013|
|Experimental: Pulpal anesthesia||
Drug: 3% mepivacaine/2% lidocaine with 1:100,000 epinephrine combo
1.8 mL of 3% mepivacaine followed by 1.8 mL of 2% lidocaine with 1:100,000 epinephrine compared to an injection of 1.8 mL of 2% lidocaine with 1:100,000 epinephrine followed by 1.8 mL of 2% lidocaine with 1:100,000 epinephrine.
- Pulpal anesthesia [ Time Frame: 60 minutes per injection sequence. ]An electric pulp tester will be used to test the lower jaw teeth (molars, premolars, and incisors) for anesthesia (numbness) in 4-minute time cycles for 60 minutes.
- Pain of injection [ Time Frame: Initial 3 minutes of study. ]A Heft-Parker Visual Analog Scale (VAS) will be used by subjects to rate the pain of injections received at three distinct times - during needle insertion, placement of the needle to target site, and deposition of the anesthetic solution at the target site. This will occur at each appointment during the anesthetic injection phase of treatment (first 3 minutes).
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01574807
|United States, Ohio|
|The Ohio State University College of Dentistry, Postle Hall|
|Columbus, Ohio, United States, 43210|
|Principal Investigator:||John Nusstein, DDS, MS||Chair, Division of Endodontics|