Regional Distribution of Ventilation to Assess Respiratory Muscle Dysfunction (DREM)
|ClinicalTrials.gov Identifier: NCT01569217|
Recruitment Status : Enrolling by invitation
First Posted : April 3, 2012
Last Update Posted : May 1, 2017
|Condition or disease|
|Respiratory Failure Neuromuscular Disorder Diaphragmatic Paralysis|
All patients which had suspected respiratory muscle dysfunction will have usual exploration of the respiratory muscles according to the clinician prescription. These explorations can include :
- Lung volumes in seating and supine position
- Maximal inspiratory and expiratory pressures
- Maximal sniff pressures
And when diaphragmatic dysfunction is suspected :
- Maximal transdiaphragmatic pressure
- Phrenic nerve conduction
These patients will also beneficiate to the determination of volume variations of the upper rib cage, the lower rib cage and the abdominal compartments by using Opto-electronic plethysmography.
|Study Type :||Observational|
|Estimated Enrollment :||200 participants|
|Official Title:||Construction of a Database to Identify Early Indicators of Respiratory Muscle Dysfunction in Neuromuscular Patients From the Optoelectronic Plethysmography Assessment of the Thoracoabdominal Motion|
|Study Start Date :||June 2011|
|Estimated Primary Completion Date :||June 2018|
|Estimated Study Completion Date :||July 2018|
respiratory muscle dysfunction patients
patients who present orthopnea, recruitment of accessory muscles, abdominal paradox, respiratory dysfunction or dyssynchronous movement
- compartmental distribution of the inspired/expired volumes [ Time Frame: 1 hour ]
Measurements of the thoraco-abdominal motion and of the global lung volume changes.
Measurements will be done during spontaneous breathing and during vital capacity maneuvers. Therefore the tidal volume, the inspiratory capacity and the expiratory reserve volume will be measured in liters and for each compartiment (upper thorax, lower thorax, abdomen) contribution of these volumes will be expressed in percentage.
- left side and right side contribution to the inspired/expired volumes [ Time Frame: 1 hour ]Measurements will be done during spontaneous breathing and during vital capacity maneuvers. Therefore the tidal volume, the inspiratory capacity and the expiratory reserve volume will be measured in liters and each side contribution of these volumes will be expressed in percentage.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01569217
|Raymond Poincaré Hospital|
|Garches, France, 92380|
|Principal Investigator:||Frédéric Lofaso, MD, PhD||Centre d'Investigation Clinique et Technologique 805|