Schistosomiasis Effect on Response to Vaccines, Anaemia and Nutritional Status of Children of Northern Senegal (SchistoVAN)
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|ClinicalTrials.gov Identifier: NCT01553552|
Recruitment Status : Completed
First Posted : March 14, 2012
Last Update Posted : March 14, 2012
|Condition or disease|
|Schistosomiasis Anemia Underweight Stunting Intestinal Parasites|
SchistoVAN aims to study the interactions between chronic parasite infections such as schistosomiasis and the immunological and nutritional status of children. In this scope, the investigators conducted a case-control study where one group of children is infected with schistosoma haematobium and the other is not infected with this parasite.
The investigators then stimulated whole blood of these children with various vaccine antigens to address their immune function and study the influence of schistosomiasis infectious state on their overall immune condition.
Aims of the study:
To evaluate the interaction between schistosomiasis and the nutritional status of children and their haemoglobinemia.
To evaluate the influence of schistosomiasis on children's specific immune response towards EPI vaccine antigens, the inflammatory status of children and nutritional serologic markers.
To compare schistosomiasis diagnostic tools (evaluation of circulating cathodic antigen (CCA) strip for diagnosis of urinary schistosomiasis in comparison with microscopy and urinary dipsticks)
To study prevalence of intestinal parasites such as Blastocystis hominis
|Study Type :||Observational|
|Actual Enrollment :||99 participants|
|Observational Model:||Case Control|
|Official Title:||Comparison of Schistosomiasis Diagnostic Techniques and Study of Schistosoma Infection on Children's Immune Response to Childhood Vaccines, on Anaemia and on Nutritional Status|
|Study Start Date :||October 2011|
|Actual Primary Completion Date :||October 2011|
|Actual Study Completion Date :||October 2011|
|Infected by Schistosoma haematobium|
|Not infected by Schistosoma haematobium|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01553552
|Biomedical Research Center EPLS|
|Saint-Louis, SL, Senegal|
|Study Chair:||Emmanuel Hermann, PhD A.Pr.||Biomedical Research Center EPLS|
|Study Director:||Lobna Gaayeb, VetMed||Biomedical Research Center EPLS|
|Principal Investigator:||Modou Seck, MD||Biomedical Research Center EPLS|