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Impact of Sarpogrelate in the Function of Endothelial Progenitor Cells

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified March 2012 by Keiko Naruse, Aichi Gakuin University.
Recruitment status was:  Recruiting
Information provided by (Responsible Party):
Keiko Naruse, Aichi Gakuin University Identifier:
First received: March 5, 2012
Last updated: NA
Last verified: March 2012
History: No changes posted
The purpose of this study is to evaluate the effects of Sarpogrelate in endothelial progenitor cells of patients with atherosclerosis.

Condition Intervention
Drug: Sarpogrelate

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Impact of Sarpogrelate in the Function of Endothelial Progenitor Cells

Resource links provided by NLM:

Further study details as provided by Keiko Naruse, Aichi Gakuin University:

Primary Outcome Measures:
  • The number and function of endothelial progenitor cells [ Time Frame: 3 months ]

Estimated Enrollment: 20
Study Start Date: October 2010
Estimated Study Completion Date: October 2012
Estimated Primary Completion Date: October 2012 (Final data collection date for primary outcome measure)
Intervention Details:
    Drug: Sarpogrelate
    Sarpogrelate 300mg/day
Detailed Description:
Endothelial progenitor cells play an important role in vasculogenesis and vascular repair. Sarpogrelate, a inhibitor of HT2A, is used an an anti-platelet drug, however, a direct effect in vascular cells is supposed.

Ages Eligible for Study:   20 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients with atherosclerosis

Exclusion Criteria:

  • Patients with high risk of bleeding
  • Patients with pregnancy
  • Patients with allergic reaction of Salpogrelate
  Contacts and Locations
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Please refer to this study by its identifier: NCT01548274

Aichi-Gakuin University Recruiting
Nagoya, Aichi, Japan, 464-8651
Contact: Keiko Naruse, M.D., Ph.D.    +81-52-759-2111 ext 5369   
Sponsors and Collaborators
Aichi Gakuin University
  More Information

Responsible Party: Keiko Naruse, Associate professor, Aichi Gakuin University Identifier: NCT01548274     History of Changes
Other Study ID Numbers: AGU-65
Study First Received: March 5, 2012
Last Updated: March 5, 2012

Keywords provided by Keiko Naruse, Aichi Gakuin University:
endothelial progenitor cells

Additional relevant MeSH terms:
Arterial Occlusive Diseases
Vascular Diseases
Cardiovascular Diseases
Fibrinolytic Agents
Fibrin Modulating Agents
Molecular Mechanisms of Pharmacological Action
Platelet Aggregation Inhibitors
Serotonin Antagonists
Serotonin Agents
Neurotransmitter Agents
Physiological Effects of Drugs processed this record on May 25, 2017