Blood Vessel Study
|ClinicalTrials.gov Identifier: NCT01524549|
Recruitment Status : Enrolling by invitation
First Posted : February 2, 2012
Last Update Posted : October 19, 2017
- The endothelium is the inner lining of blood vessels. The cells in this lining help regulate blood flow and immune system function. Problems with endothelial cells can contribute to heart disease, high blood pressure, and diabetes. Certain genes or parts of genes may be related to problems with endothelial function. Researchers want to study healthy adults who have genes that may affect their endothelial function. More information on these genes may provide more information on genetic risk for certain diseases.
- To study healthy adults who have genetic markers related to endothelial cell problems.
- Healthy volunteers between 18 and 65 years of age.
- Current participants of the Environmental Polymorphisms Registry and have certain genes related to endothelial cell problems.
- Participants will have a single study visit to collect information and samples.
- Participants will be screened with a physical exam and medical history. Blood and urine samples will be collected.
- Participants will have an ultrasound of the artery in the arm and will be given a short-acting medication called nitroglycerin to study blood flow and blood pressure.
|Condition or disease|
|Endothelial Cell Function|
|Study Type :||Observational|
|Actual Enrollment :||172 participants|
|Official Title:||The Role of the Functionally Relevant Single Nucleotide Polymorphisms CYP2J2 -50G>T (CYP2J2 7) and EPHX2 9846A>G (EPHX2 K55R) in Human Endothelial Function|
|Study Start Date :||January 17, 2012|
- Flow-mediated dilation (FMD; endothelium-dependent vasodilation), defined as the peak percent change in brachial artery diameter, relative to baseline, after reactive hyperemia, as measured by ultrasound
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01524549
|United States, North Carolina|
|NIEHS Clinical Research Unit (CRU)|
|Research Triangle Park, North Carolina, United States|
|Principal Investigator:||Darryl C Zeldin, M.D.||National Institute of Environmental Health Sciences (NIEHS)|