Brown Fat Activity and White Fat Accumulation
This study has been completed.
First Posted: January 25, 2012
Last Update Posted: January 25, 2012
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Information provided by (Responsible Party):
Vicente Gilsanz, Children's Hospital Los Angeles
White and brown adipocytes differ in their expression of hormones, cytokines, and inflammatory factors, and they modulate different biological functions. While white adipose tissue (WAT) serves as the primary site of energy storage, brown adipose tissue (BAT) instead metabolizes fat to produce heat and regulate body temperature. BAT is likely present in all humans, but the low prevalence of BAT depiction in adults and elderly subjects has hindered longitudinal assessments of the relation between BAT activity and WAT. Under typical imaging conditions, BAT is detected more frequently in children and teenagers than in adults with malignancy. Since most children with cancer have significantly shorter treatment courses and greater survival rates compared to adult patients, the investigators have the ability to examine the relation of repeated measures of body composition and BAT by selecting pediatric patients. In this study, the investigators will longitudinally examine whether BAT activity is related to changes in weight and the amounts of SAT, VAT, and abdominal muscle in children successfully treated for pediatric cancer.
||Observational Model: Cohort
Time Perspective: Retrospective
||Study on the Association Between Brown Adipose Tissue Activation and White Adipose Tissue Accumulation in Successfully Treated Pediatric Malignancy
Primary Outcome Measures:
- Change from Baseline in Subcutaneous Adipose Tissue Volume at Follow-up [ Time Frame: Baseline and up to 1 year ]
- Change from Baseline in Visceral Adipose Tissue Volume at Follow-up [ Time Frame: Baseline and up to 1 year ]
- Change from Baseline in Presence of Brown Adipose Tissue [ Time Frame: Baseline and up to 1 year ]
- Change from Baseline in Abdominal Musculature Volume [ Time Frame: Baseline and up to 1 year ]
Secondary Outcome Measures:
| Study Start Date:
| Study Completion Date:
| Primary Completion Date:
||September 2011 (Final data collection date for primary outcome measure)
Malignant Disease with no visualized BAT
Children 18 years or younger who 1) had PET/CT scans with evidence of malignant disease but no metabolically active brown adipose tissue (BAT) at diagnosis and 2) were disease free within 1 year of diagnosis.