Correlation of PaCO2 to the Inspired and Expired Oxygen Gradient (O2 Fraction)
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ClinicalTrials.gov Identifier: NCT01513213 |
Recruitment Status :
Completed
First Posted : January 20, 2012
Last Update Posted : January 24, 2017
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Condition or disease |
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Neurosurgery |
Study Type : | Observational |
Actual Enrollment : | 65 participants |
Observational Model: | Case-Only |
Time Perspective: | Cross-Sectional |
Official Title: | Correlation of PaCO2 to the Inspired and Expired Oxygen Gradient |
Study Start Date : | October 2011 |
Actual Primary Completion Date : | May 2014 |
Actual Study Completion Date : | December 2016 |

- Correlate the level of carbon dioxide within arterial blood to inspired and expired oxygen gradient. [ Time Frame: At least 2 hours ]Compare the levels of carbon dioxide found in the patient's blood to the amounts of carbon dioxide and oxygen in the air that the patient inhales and exhales. If a relationship exists between the levels of carbon dioxide in the blood and the levels of carbon dioxide and oxygen inhaled and exhaled by the patient, anesthesiologists will be able to use this relationship to adjust ventilators during anesthesia without having to take blood from an artery.

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Ages Eligible for Study: | 18 Years to 65 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- Age 18 to 65.
- Scheduled for surgical procedure that will last at least 2 hours.
- Arterial cannulation is planned because of either the complexity of the surgery or patient comorbidity.
- At least two arterial blood gas analyses are planned during the surgery.
Exclusion Criteria:
- No arterial cannulation is necessary or planned for the procedure.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01513213
United States, Washington | |
Swedish Medical Center | |
Seattle, Washington, United States, 98122 |
Principal Investigator: | Arthur M Lam, MD, FRCPC | Swedish Medical Center |
Responsible Party: | Swedish Medical Center |
ClinicalTrials.gov Identifier: | NCT01513213 History of Changes |
Other Study ID Numbers: |
5119S-11 |
First Posted: | January 20, 2012 Key Record Dates |
Last Update Posted: | January 24, 2017 |
Last Verified: | January 2017 |
Arterial cannulation Blood gas Carbon dioxide |
Arterial blood Oxygen Oxygen fractions |
Respiratory Aspiration Respiration Disorders Respiratory Tract Diseases Pathologic Processes |