Effect of a Component of Fish Oil on Exercise-Induced Bronchoconstriction and Airway Inflammation in Asthma
|ClinicalTrials.gov Identifier: NCT01504646|
Recruitment Status : Completed
First Posted : January 5, 2012
Last Update Posted : April 4, 2013
|Condition or disease||Intervention/treatment||Phase|
|Asthma Exercise-Induced Bronchoconstriction||Dietary Supplement: Lyprinol Dietary Supplement: Placebo (Olive Oil)||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||20 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||Double (Participant, Investigator)|
|Primary Purpose:||Basic Science|
|Official Title:||Randomized Controlled Trial of Marine Lipid Fraction PCSO-524™ on Airway Inflammation and Hyperpnea-Induced Bronchoconstriction in Asthma|
|Study Start Date :||January 2012|
|Actual Primary Completion Date :||August 2012|
|Actual Study Completion Date :||August 2012|
Placebo Comparator: Olive Oil Capsule
Ten subjects will take eight placebo olive oil capsules per day for three weeks.
Dietary Supplement: Placebo (Olive Oil)
8 capsules (1 capsule = 100mg olive oil) per day for 3 weeks
Other Name: Olive Oil
Ten subjects will take eight Lyprinol capsules per day for three weeks.
Dietary Supplement: Lyprinol
8 capsules (1 capsule=50mg n-PUFA, 100mg olive oil) per day for 3 weeks
- Pulmonary Function (Percent Change in FEV1, measured in Liters) [ Time Frame: 8 weeks ]The percent change in FEV1 is the percent change in the volume of air exhaled during the first second of a forced exhalation as measured before and after the surrogate exercise challenge.
- Fraction of Exhaled Nitric Oxide [ Time Frame: 8 weeks ]The concentration of exhaled Nitric Oxide (measured as parts per billion) will be measured using a Nitric Oxide Analyzer.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01504646
|United States, Indiana|
|Indiana University School of Health, Physical Education, and Recreation|
|Bloomington, Indiana, United States, 47405|