Ultrastructure of Atrial Myocytes in Patients in Sinus Rhythm and With Atrial Fibrillation
|ClinicalTrials.gov Identifier: NCT01493128|
Recruitment Status : Completed
First Posted : December 15, 2011
Last Update Posted : March 13, 2017
The aim of this work is to study the prevalence of T-tubular system in left and right myocytes from patients in sinus rhythm and whether this is altered in paroxysmal and permanent atrial fibrillation. Furthermore, since current information is lacking on the key Ca2+-handling proteins RyR, NCX, and SERCA-2a from patients in Atrial Fibrillation (AF), it will be investigated whether a regulation of these proteins could be an underlying cause of the disease. Mitochondrial function will also studied.
- The investigators hypothesize that both structure of sarcolemma and localization of key Ca2+-handling proteins are altered in patients with atrial fibrillation compared with patients in sinus rhythm.
- The investigators hypothesize that mitochondrial function is altered in patients with atrial fibrillation compared with patients in sinus rhythm.
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||45 participants|
|Official Title:||Ultrastructure of Sarcolemma, Immunofluorescence of Calcium Handling Proteins and Mitochondrial Function in Atrial Myocytes of Patients in Sinus Rhythm and With Atrial Fibrillation|
|Actual Study Start Date :||April 2010|
|Primary Completion Date :||February 2012|
|Study Completion Date :||July 2012|
|stable sinus rhythm|
|permanent atrial fibrillation|
|paroxysmal atrial fibrillation|
- structure of sarcolemma [ Time Frame: 1 hour ]
Biospecimen Retention: Samples Without DNA
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01493128
|Study Director:||Ulrik Wisløff, PhD||Norwegian University of Science and Technology|