A Study to Find Out How Much Mirabegron Gets Into the Body After Dosing With a Tablet Formulation
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A study to evaluate how much of the active compound of mirabegron comes into the blood circulation when given as a controlled-release pill as compared to given intravenously.
Condition or disease
Pharmacokinetics of MirabegronBioavailabilityHealthy Subjects
Drug: mirabegron OCASDrug: mirabegron
All participants will receive both oral and iv formulations, separated by a washout period. Treatment arm A will receive a lower dose of mirabegron; Treatment arm B will receive a higher dose of mirabegron.
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Ages Eligible for Study:
18 Years to 55 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Body weight between 60.0 and 100.0 kg and Body Mass Index between 18.0 and 30.0 kg/m2
Known or suspected hypersensitivity to β-adrenergic receptor agonists or constituents of the formulations used
Clinically significant elevation of serum creatinine or liver enzymes as evidenced by creatinine >150 ųmol/L; ASAT, ALAT or LDH> 2x ULN; ɣ-GT > 3x ULN and/or abnormal serum bilirubin
Any clinically significant history of asthma, eczema, any other allergic condition or previous severe hypersensitivity to any drug
Subjects taking β blockers or β agonists (eye drops allowed)
Any clinically significant history of upper gastrointestinal symptoms (such as nausea, vomiting, abdominal discomfort or upset, or heartburn) in the 4 weeks prior to the first admission to the Research Unit
Any clinically significant history of any other disease or disorder - gastrointestinal, cardiovascular, respiratory, ophthalmologic, renal, hepatic, neurological, dermatological, psychiatric or metabolic
Any clinically significant abnormality following the investigator's review of the pre-study physical examination, ECG and clinical laboratory tests
QTcB interval of > 430 (mean QTcB of two measurements > 430msec)
Abnormal pulse rate measurement (<40 or >90 bpm) at the pre-study visit after subject has been resting in supine position for 5 min.
Abnormal blood pressure measurements taken at the pre-study visit after subject has been resting in supine position for 5 min as follows:
Systolic blood pressure <95 or >160 mmHg
Diastolic blood pressure <40 or >90 mmHg
Positive orthostatic test at screening i.e. any symptoms of dizziness, light-headedness etc. and a fall of > 20 mmHg in systolic blood pressure after 2 min standing and an increase in pulse rate of ≥ 20 bpm
Regular use of any prescribed or OTC drugs except paracetamol up to 3 g/day, in the 4 weeks prior to admission to the Research Unit OR any use of such drugs in the 2 weeks prior to first admission to the Research Unit