Working Memory Training in Adults With ADHD (DAT1-PRIMA)

• Change in a composite measure of working memory capacity [ Time Frame: Baseline and 7 weeks ] [ Designated as safety issue: No ]

  The composite measure of working memory capacity comprises the sum score of:

  • Digit Span score (forwards/backwards)
  • Span Board score (forwards/backwards)
  • Arithmetics score
  • Spatial Working Memory score
  
  

• Change in a composite measure of working memory capacity [ Time Frame: Baseline and 31 weeks ] [ Designated as safety issue: No ]
  The composite measure of working memory capacity will be assessed in a 6-month follow-up conducted at week 31 post-baseline, equivalent to week 24 post-intervention, to assess retention of any training-related improvements.
  
  
• Change in Digit Span Forwards/Backwards score [ Time Frame: Baseline, 7 and 31 weeks ] [ Designated as safety issue: No ]
  Evaluating changes in both Digit Span forwards and backwards scores, as measures of simple verbal working memory capacity.
  
  
• Change in Span Board Forwards/Backwards score [ Time Frame: Baseline, 7 and 31 weeks ] [ Designated as safety issue: No ]
  Evaluating changes in both Span Board forwards and backwards scores as measures of simple visuo-spatial working memory capacity.
  
  
• Change in Arithmetics score [ Time Frame: Baseline, 7 and 31 weeks ] [ Designated as safety issue: No ]
  Evaluating change in Arithmetics score, as a measure of complex verbal working memory capacity as well as of mathematics ability.
  
  
• Change in Spatial Working Memory score [ Time Frame: Baseline, 7 and 31 weeks ] [ Designated as safety issue: No ]
  Evaluating change in Spatial Working Memory score as a measure of complex visuo-spatial working memory capacity.
  
  
• Change in Qbtest scores [ Time Frame: Baseline, 7 and 31 weeks ] [ Designated as safety issue: No ]
  Evaluating changes in Qbtest, a computerised CPT that in addition to measuring inattention and impulsivity also captures motor activity by an IR device during performance of the CPT.
  
  
• Change in Raven´s Standard Progressive Matrices score [ Time Frame: Baseline, 7 and 31 weeks ] [ Designated as safety issue: No ]
  Evaluating change in score of a short version of Raven´s Standard Progressive Matrices, as a measure of fluid intelligence.
  
  
• Change in Adult ADHD Self-Report Scale (ASRS-v1.1) Symptom Checklist [ Time Frame: Baseline, 7, 19, and 31 weeks ] [ Designated as safety issue: No ]
  Evaluating changes in ADHD symptoms by self-reported and informant-reported (significant other) versions of ASRS-v1.1, conducted at baseline, post-intervention, at 3-month and 6-month follow-up.
  
  
• Change in Sheehan Disability Scale (SDS) [ Time Frame: Baseline, 7, 19, and 31 weeks ] [ Designated as safety issue: No ]
  Evaluating changes in psychosocial functioning by the self-reported SDS conducted at baseline, post-intervention, at 3-month and 6-month follow-up.
  
  
• Change in EuroQol- 5 Dimensions (EQ-5D) questionnaire [ Time Frame: Baseline, 7, 19, and 31 weeks ] [ Designated as safety issue: No ]
  Evaluating change in health-related quality of life by the self-reported generic QoL questionnaire EQ-5D, conducted at baseline, post-intervention, at 3-month and 6-month follow-up.
  
  
• Change in Adult ADHD Quality of Life Measure (AAQoL) [ Time Frame: Baseline, 7, 19, and 31 weeks ] [ Designated as safety issue: No ]
  Evaluating change in health-related quality of life by the self-reported ADHD specific QoL measure AAQoL, conducted at baseline, post-intervention, at 3-month and 6-month follow-up.
  
  
• Montgomery Åsberg Depression Rating Scale-Self report (MADRS-S) [ Time Frame: Baseline and 7 weeks ] [ Designated as safety issue: No ]
  Evaluating if depressive symptoms during the training period, as measured by the self-reported MADRS-S will influence adherence to and results of the working memory training.
  
  
• Adverse events [ Time Frame: Baseline and 7 weeks ] [ Designated as safety issue: No ]
  All adverse events that occurred during the course of the 5-week intervention will be collected as part of the post-intervention assessments at week 7.
  
  

The primary aim is to evaluate whether 5 weeks of computerised working memory training improves working memory capacity. Secondary aims are to explore whether improvements in working memory capacity will be transferred to improvements in learning abilities and fluid intelligence. Also, far transfer effects on executive functioning, ADHD symptoms, psychosocial functioning and quality of life will be explored. Finally, it will also be assessed to what extent improvements gained from 5 weeks of working memory training will be maintained 3 and 6 months post-study, respectively.