Bone Marrow Cell Engraftment of the Uterus and Genetic Studies of Reproductive Functioning
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|ClinicalTrials.gov Identifier: NCT01468935|
Recruitment Status : Completed
First Posted : November 10, 2011
Last Update Posted : January 14, 2019
- Some transplant recipients have been found to have cells in their uterus that come from the donor. Researchers want to study uterine tissue from three different groups of women: (1) healthy volunteers, (2) people who have had a stem cell transplant, and (3) people with rare diseases or conditions that affect reproduction. These samples will help researchers learn more about the way stem cells work in the reproductive tract.
- To collect cells from the uterus to study how stem cells work in the reproductive tract.
- Women at least 18 years of age.
- Participants will be screened with a physical exam and medical history. They will also have blood and urine tests.
- Participants will have an endometrial biopsy to collect cells for study. The biopsy visit will take 1 to 2 hours.
|Condition or disease|
|Endometriosis Stem Cell Transplant Healthy Volunteers|
Transplantation with hematopoietic cells has been used for a wide variety of blood disorders, but also for diseases like solid organ cancers. Interestingly, women who have had bone marrow transplants have been found to have donor tissue in their endometrium, which raises the possibility of cellular therapies using bone marrow derived cells for gynecologic indications. Donor engraftment does not appear to occur when transplantations were performed with stem cells collected from peripheral blood of the donor. Therefore, the subtype of cells from the bone marrow responsible for engraftment is not yet known, nor is the ideal transplantation regimen known.
The immediate aim of this tissue procurement protocol is to obtain endometrial (uterine) stem cells from many human volunteers in order to examine the biological properties of those cells. We will collect tissue from 3 primary groups of patients: normal controls, patients with rare diseases or reproductive disorders, and patients who have undergone hematopoietic stem cell transplant. Each volunteer will undergo an endometrial biopsy during an office visit. The endometrial tissue will then be studied for a better understanding of their biological properties, growth and differentiation. One specific area of interest is to study how hematopoietic transplantation impacts endometrial cell function. These endometrial cells will be analyzed in-depth in the laboratory to determine if they came from the donor or recipient, and if so, which specific populations of cells. Hematologic pre-transplant conditioning information will be correlated with these research studies to identify factors that may assist with the understanding of adult endometrial stem cell biology.
|Study Type :||Observational|
|Actual Enrollment :||79 participants|
|Official Title:||Bone Marrow Cell Engraftment of the Uterus and Genetic Studies of Reproductive Functioning|
|Study Start Date :||October 31, 2011|
|Study Completion Date :||September 21, 2017|
- To study if endometiral stem cells are different in normal and disease states.
- To study if the type of hematopoietic transplantation regimen affects uterine engraftment of donor stem cells.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01468935
|United States, Maryland|
|National Institutes of Health Clinical Center, 9000 Rockville Pike|
|Bethesda, Maryland, United States, 20892|
|Principal Investigator:||Alan H DeCherney, M.D.||Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|