Noninvasive Biomarkers for Monitoring Cardiometabolic Risk in Children
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ClinicalTrials.gov Identifier: NCT01465789
Recruitment Status :
(Loss of participants to follow-up)
First Posted : November 7, 2011
Last Update Posted : August 7, 2013
West Virginia School of Osteopathic Medicine
Information provided by (Responsible Party):
Kristie Bridges, West Virginia School of Osteopathic Medicine
The purpose of this study is to identify salivary biomarkers for monitoring cardiometabolic risk in children. The study hypothesis is that a combination of salivary biomarkers will predict the presence of risk factors including impaired fasting glucose, hypertension and dyslipidemia and will reflect changes in these risk factors over time.
Correlation (R values) of salivary biomarkers with blood pressure percentile and serum glucose, HDL, total cholesterol, triglyceride and insulin levels in children [ Time Frame: Baseline ]
Predictive utility (C-statistic) of salivary biomarkers for development of metabolic syndrome during childhood and adolescence [ Time Frame: final assessment at age 18 (up to 14 years depending on age of enrollment) ]
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Ages Eligible for Study:
4 Years to 17 Years (Child)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Children participating in the CARDIAC Boot Camp program at the Robert C. Byrd Clinic in Lewisburg WV
Participating in the CARDIAC Boot Camp Program
Between the ages of 4 and 17
Ability to provide assent
Inability to comply with saliva collection procedures