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Detection of Helicobacter Pylori Infection by High Resolution Endoscopy

This study has been completed.
Information provided by (Responsible Party):
Jun-Hyung Cho, Kyunghee University Medical Center Identifier:
First received: September 14, 2011
Last updated: April 19, 2012
Last verified: April 2012
Although endoscopic findings of H. pylori have been reported in the literature, there is still some debate over whether H. pylori-related gastritis can be diagnosed via endoscopic features alone. Most studies concluded that it is not possible to diagnose H. pylori-related gastritis on the basis of endoscopic findings. However, the resolution power of endoscopy has greatly improved in recent years and the exact examination of gastric mucosa was possible.

Helicobacter-associated Gastritis

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Detection of Helicobacter Pylori Infection by Non-magnifying High Resolution Endoscopy is Possible Within the Gastric Corpus

Resource links provided by NLM:

Further study details as provided by Jun-Hyung Cho, Kyunghee University Medical Center:

Primary Outcome Measures:
  • Diagnosis accuracy for predicting of Helicobacter pylori infection status [ Time Frame: 1 day ]

Secondary Outcome Measures:
  • Assessment of the clinicopathologic factors related to correct diagnosis [ Time Frame: 7 days ]

Biospecimen Retention:   Samples Without DNA
Gastric mucosa for detecting Helicobacter pylori

Enrollment: 585
Study Start Date: August 2011
Study Completion Date: January 2012
Primary Completion Date: January 2012 (Final data collection date for primary outcome measure)
H. pylori gastritis

Detailed Description:
Our study aimed to achieve the following: (1) describe the H. pylori-related mucosal pattern in the gastric corpus using high-definition endoscopy; (2) evaluate the diagnostic accuracy for H. pylori detection; (3) find the optimal biopsy site for rapid urease test (RUT); (4) validate the inter- and intraobserver agreement in the assessment of endoscopic patterns.

Ages Eligible for Study:   20 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients who underwent upper endoscopy in the Kyung Hee University Hospital

Inclusion Criteria:

  • Patients who underwent upper endoscopy

Exclusion Criteria:

  • Age < 20 or > 70
  • Severe systemic disease or advanced chronic liver disease
  • Medication history of NSAID, PPI, H2 blockers or antibiotics
  • History of H. pylori eradication therapy
  • History of gastric surgery
  • Recent history of upper GI bleeding
  • Gastric or duodenal ulcer (including old scar change) during endoscopy
  • Anemia (Hemoglobin level < 10mg/dL)
  • Pangastritis
  Contacts and Locations
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Please refer to this study by its identifier: NCT01434992

Korea, Republic of
Kyung Hee University Hospital
Seoul, Korea, Republic of, 82
Sponsors and Collaborators
Kyunghee University Medical Center
Principal Investigator: Jun-Hyung Cho, M.D. Kyung Hee University Hospital
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Jun-Hyung Cho, Clinical and research fellow, Kyunghee University Medical Center Identifier: NCT01434992     History of Changes
Other Study ID Numbers: KHU-HP-2011
Study First Received: September 14, 2011
Last Updated: April 19, 2012

Additional relevant MeSH terms:
Helicobacter Infections
Gram-Negative Bacterial Infections
Bacterial Infections
Gastrointestinal Diseases
Digestive System Diseases
Stomach Diseases processed this record on September 18, 2017