A Prospective Epidemiological Research on Functioning Outcomes Related to Major Depressive Disorder (PERFORM)
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Patients' functioning assessed by the Sheehan Disability Scale (SDS) total score [ Time Frame: At baseline ]
Patients' functioning assessed by the SDS total score [ Time Frame: At 12 months ]
Secondary Outcome Measures
Associations between the patients' clinical condition measured as score on Clinical Global Improvement Severity scale (CGI-S) and of patients' functioning measured as total score on SDS [ Time Frame: At baseline ]
Associations between the patients' clinical condition measured as score on CGI-S and of patients' functioning measured as total score on SDS [ Time Frame: At 12 months ]
Associations between the patients' clinical condition measured as score on CGI-S and of patients' functioning measured as total score on SDS [ Time Frame: At 24 months ]
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Ages Eligible for Study:
18 Years to 65 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients will be recruited from outpatient clinics (General Practitioner (GP) or psychiatrist)
Outpatients with a current or new diagnosis of major depressive episode (MDE) according to the Diagnostic and Statistical Manual of Mental Disorders IV Text Revision (DSM-IV-TR); diagnosis will be confirmed through the Mini International Psychiatric Interview (MINI) questionnaire (depression module)
Outpatients starting an antidepressant treatment in monotherapy at baseline (treatment initiation or first treatment switch) as decided by the treating physician
The patient will present within the normal course of care, for either a first or subsequent episode of depression
Schizophrenia or other psychotic disorders
Dementia or other neurodegenerative disease significantly impacting cognitive functioning
Mood disorder due to a general medical condition or substances
Patient treated for depression by a combination of different antidepressant treatments at the time of the consultation