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Systemic Effects of Epidural Methylprednisolone Injection on Glucose Tolerance in Diabetic Patients

This study has been completed.
ClinicalTrials.gov Identifier:
First Posted: August 19, 2011
Last Update Posted: August 19, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
zufferey Pascal, Centre Hospitalier Universitaire Vaudois
Several studies have shown that in diabetic patients, the glycemic profile was disturbed after intra-articular injection of corticosteroids. Little is known about the impact of epidural injection in such patients. The goal of this study was double, at first comparing the glycaemic profile in diabetic patients after a unique injection of 80 mg of acetate methylprednisolone either intra-articular or epidural, secondly to compare the amount of systemic diffusion of the drug the after both procedures.

Condition Intervention
Diabetes Healthy Drug: intra-articular infiltration Drug: epidural infiltration

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Prevention

Resource links provided by NLM:

Further study details as provided by zufferey Pascal, Centre Hospitalier Universitaire Vaudois:

Primary Outcome Measures:
  • glycemic values, [ Time Frame: day 0 to day 15 ]

Secondary Outcome Measures:
  • urinary excretion rate [ Time Frame: day 0 to day 15 ]

Enrollment: 25
Study Start Date: August 2008
Study Completion Date: June 2010
Primary Completion Date: September 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: methylprednisolone,infiltration Drug: intra-articular infiltration
intra articular infiltration
Active Comparator: epidural injection Drug: epidural infiltration
epidural infiltration


Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • diabetes stable for more than ten days
  • no contraindication for steroids
  • lumbar stenosis
  • articular pain

Exclusion Criteria:

  • unstable diabetes
  • renal insufficiency
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01420497

Lausanne, VD, Switzerland, 1001
Sponsors and Collaborators
Centre Hospitalier Universitaire Vaudois
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: zufferey Pascal, md, Centre Hospitalier Universitaire Vaudois
ClinicalTrials.gov Identifier: NCT01420497     History of Changes
Other Study ID Numbers: gylperi
First Submitted: August 18, 2011
First Posted: August 19, 2011
Last Update Posted: August 19, 2011
Last Verified: August 2011

Keywords provided by zufferey Pascal, Centre Hospitalier Universitaire Vaudois:
intra articular infiltration
epidural infiltration

Additional relevant MeSH terms:
Prednisolone acetate
Methylprednisolone acetate
Methylprednisolone Hemisuccinate
Prednisolone hemisuccinate
Prednisolone phosphate
Anti-Inflammatory Agents
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Gastrointestinal Agents
Hormones, Hormone Substitutes, and Hormone Antagonists
Neuroprotective Agents
Protective Agents
Antineoplastic Agents, Hormonal
Antineoplastic Agents