Efficacy of Bitter Blockers on Taste Perception in Children and Adults (BL)
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|ClinicalTrials.gov Identifier: NCT01407939|
Recruitment Status : Completed
First Posted : August 2, 2011
Last Update Posted : March 16, 2016
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||215 participants|
|Official Title:||Efficacy of Bitter Taste Blockers on Flavor Acceptance in Pediatric Populations|
|Study Start Date :||April 2011|
|Actual Primary Completion Date :||March 2016|
|Actual Study Completion Date :||March 2016|
3- to 15-year old children and their parent (adults
- Proportion of subjects who rate bitter solutions with added bitter blockers as less bitter than the bitter solution alone. [ Time Frame: 2 hours ]Primary outcome variables are the proportion of subjects by age group (children and adults) judging a variety of GRAS bitter compounds with a bitter blocker as less bitter or more pleasant than the bitter compound alone (the efficacy of the bitter blocker). At least 5 bitter compounds and 5 GRAS bitter blockers will be used. We will determine how these measures are affected by the age and genotype of the subjects.
- Biometrics and Genotype [ Time Frame: One year ]For both Studies 1 and 2, the secondary outcome variables include age, genotype of various taste receptor genes (e.g., TAS2R38, TAS2R20, TAS2R31), body weight and height.
- Differences in bitterness ratings obtained via different pediatric taste-assessment methodologies. [ Time Frame: 2 hours ]We will determine whether the bitter-blocker pairings assessed as most effective by the children using the forced-comparison procedure (bitter alone vs bitter plus blocker) yield statistically different ratings when children use a 3-point, 5-point, or 7-point scale (with happy and sad faces to denote the degree of liking and disliking) after children, of varying ages, taste each of these solutions.
Biospecimen Retention: Samples With DNA
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01407939
|United States, Pennsylvania|
|Monell Chemical Senses Center|
|Philadelphia, Pennsylvania, United States, 19104|
|Principal Investigator:||Julie A. Mennella, PhD||Monell Chemical Senses Center|