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The Effect of Experimental Knee Pain During Strengthening Exercises on Muscle Strength Gain

This study has been completed.
Information provided by:
Frederiksberg University Hospital Identifier:
First received: May 2, 2011
Last updated: May 3, 2011
Last verified: February 2010
The purpose of this study is to evaluate the effects of experimental knee pain on the muscle strength gain after 8 weeks of strengthening exercises for the quadriceps. It is hypothesized that experimental knee pain will reduce the muscle strength gain following strengthening exercises in healthy volunteers.

Condition Intervention
Muscle Strength
Other: Experimental knee pain
Other: Non-painful control injections

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: The Effect of Experimental Knee Pain During Strengthening Exercises on Muscle Strength Gain

Resource links provided by NLM:

Further study details as provided by Frederiksberg University Hospital:

Primary Outcome Measures:
  • Isokinetic knee muscle strength [ Time Frame: At baseline and after 8 weeks of exercise ]

Secondary Outcome Measures:
  • One-leg chair rise [ Time Frame: At baseline and after 8 weeks of exercise ]

Enrollment: 36
Study Start Date: February 2010
Study Completion Date: August 2010
Primary Completion Date: August 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Experimental Knee Pain
Experimental knee pain induced by injections of 1 ml hypertonic saline in to the infrapatellar fat pad
Other: Experimental knee pain
Injection of 1 ml hypertonic saline (5.8%) into the infrapatellar fat pad
Active Comparator: Control
non-painful injections of isotonic saline into the infrapatellar fatpad.
Other: Non-painful control injections
Injection of isotonic saline into the infrapatellar fat pad


Ages Eligible for Study:   20 Years to 35 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • aged between 20 to 35 years
  • healthy
  • untrained (non-regular exercise participation [i.e. < 1 day/week])

Exclusion Criteria:

  • symptomatic musculoskeletal diseases
  • history of traumatic injuries to muscles, tendons or joints of the lower extremity
  • knee joint pain within a month prior to enrollment
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No Contacts or Locations Provided
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Henning Bliddal, The Parker Institute Identifier: NCT01346995     History of Changes
Other Study ID Numbers: 072.07
Study First Received: May 2, 2011
Last Updated: May 3, 2011 processed this record on May 22, 2017