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Acute Cardiovascular Effects of Cigarette Smoking

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01346956
First Posted: May 4, 2011
Last Update Posted: May 4, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Andhra Medical College
  Purpose
Twenty healthy smokers will be subjected to measurement of Pulse, Blood Pressure, electrocardiogram (ECG) and Echo at baseline and after smoking a cigarette. The measurements will be compare for any cardiovascular effects of a cigarette smoking on these parameters.

Condition
Smoking

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Acute Cardiovascular Effects of Cigarette Smoking

Resource links provided by NLM:


Further study details as provided by Andhra Medical College:

Enrollment: 20
Study Start Date: July 2002
Study Completion Date: August 2002
Primary Completion Date: August 2002 (Final data collection date for primary outcome measure)
Detailed Description:
Twenty male persons habituated to smoking (at least 5 cigarettes/day) will be recruited after an informed consent. Healthy persons with no systemic illness will be included. After a history and a routine examination, subjects will be asked to abstain from smoking for 3 hours and then their pulse, BP, ECG and echo recorded. The measurements will be repeated after 15 min. and the average of these two taken as baseline readings. Then, they will be asked to smoke a cigarette and the measurements taken again. Special focus will be on Doppler measures of left ventricular (LV) function. The measurements are repeated immediately and at 5,10 and 15 min. The data will be analyzed for any cardiovascular effects of smoking a cigarette. Chi square test for proportions and t-test for means will be done. A p value < 0.05 will be taken as significant.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Twenty healthy male smokers
Criteria

Inclusion Criteria:

  • Healthy male smokers (at least 5 cigarettes /day) >18 years old.

Exclusion Criteria:

  • Any cardiac or respiratory or systemic illness,including hypertension.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01346956


Locations
India
Andhra Medical College
Visakhapatnam, Andhra Pradesh, India, 530002
Sponsors and Collaborators
Andhra Medical College
Investigators
Principal Investigator: Venkatachelam R Chitrapu, MD DM Andhra Medical College
  More Information

Responsible Party: Ravi Venkatachelam Chitrapu, Andhra Medical College
ClinicalTrials.gov Identifier: NCT01346956     History of Changes
Other Study ID Numbers: 02AMCRAVSAND07
First Submitted: May 2, 2011
First Posted: May 4, 2011
Last Update Posted: May 4, 2011
Last Verified: January 2003

Keywords provided by Andhra Medical College:
Cigarette
Smoking
Cardiovascular Effects
2D Echocardiography
Doppler