Acute Cardiovascular Effects of Cigarette Smoking

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01346956
Recruitment Status : Completed
First Posted : May 4, 2011
Last Update Posted : May 4, 2011
Information provided by:
Andhra Medical College

Brief Summary:
Twenty healthy smokers will be subjected to measurement of Pulse, Blood Pressure, electrocardiogram (ECG) and Echo at baseline and after smoking a cigarette. The measurements will be compare for any cardiovascular effects of a cigarette smoking on these parameters.

Condition or disease

Detailed Description:
Twenty male persons habituated to smoking (at least 5 cigarettes/day) will be recruited after an informed consent. Healthy persons with no systemic illness will be included. After a history and a routine examination, subjects will be asked to abstain from smoking for 3 hours and then their pulse, BP, ECG and echo recorded. The measurements will be repeated after 15 min. and the average of these two taken as baseline readings. Then, they will be asked to smoke a cigarette and the measurements taken again. Special focus will be on Doppler measures of left ventricular (LV) function. The measurements are repeated immediately and at 5,10 and 15 min. The data will be analyzed for any cardiovascular effects of smoking a cigarette. Chi square test for proportions and t-test for means will be done. A p value < 0.05 will be taken as significant.

Study Type : Observational
Actual Enrollment : 20 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Acute Cardiovascular Effects of Cigarette Smoking
Study Start Date : July 2002
Actual Primary Completion Date : August 2002
Actual Study Completion Date : August 2002

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Smoking
U.S. FDA Resources

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Twenty healthy male smokers

Inclusion Criteria:

  • Healthy male smokers (at least 5 cigarettes /day) >18 years old.

Exclusion Criteria:

  • Any cardiac or respiratory or systemic illness,including hypertension.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01346956

Andhra Medical College
Visakhapatnam, Andhra Pradesh, India, 530002
Sponsors and Collaborators
Andhra Medical College
Principal Investigator: Venkatachelam R Chitrapu, MD DM Andhra Medical College

Responsible Party: Ravi Venkatachelam Chitrapu, Andhra Medical College Identifier: NCT01346956     History of Changes
Other Study ID Numbers: 02AMCRAVSAND07
First Posted: May 4, 2011    Key Record Dates
Last Update Posted: May 4, 2011
Last Verified: January 2003

Keywords provided by Andhra Medical College:
Cardiovascular Effects
2D Echocardiography