Laparoscopic Nissen Versus Toupet Fundoplication: Objective and Subjective Results of a Prospective Randomized Trial
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.
Read our disclaimer for details.
The aim of this study is to compare subjective and objective outcome and surgical "side effects" of Nissen and Toupet fundoplication performed in a single institution by only two surgeons and to compare pre and postoperative findings to healthy individuals.
Condition or disease
Gastroesophageal Reflux DiseaseLaparoscopic Antireflux Surgery
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Clinical diagnosis of gastroesophageal reflux disease
Long history of GERD symptoms
Persistent or recurrent symptoms despite optimal medical treatment
Persistent or recurrent complications of GERD
Reduced quality of life owing to increasing esophageal exposure to gastric juice
Pathological values in the preoperative evaluated functional parameters
Previous esophageal or gastric surgery
Poor physical status (American Society of Anesthesiologists (ASA) scores III and IV)