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The Role of Angiotensinogen Gene Polymorphism in the Pathogenesis of Non-familial Sick Sinus Syndrome

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01310920
Recruitment Status : Unknown
Verified March 2011 by China Medical University Hospital.
Recruitment status was:  Recruiting
First Posted : March 9, 2011
Last Update Posted : March 9, 2011
Information provided by:
China Medical University Hospital

Brief Summary:
Evidence has been documented for the close relationship between the arrhythmia pathogenesis and the gene expression in renin-angiotensin system. However, it remains unclear for involvement of RAS in the pathogenesis of non-familial sick sinus syndrome. The researchers thus investigated the possible relationship between non-familial sick sinus syndrome and the polymorphism and haplotype of the AGT promoter.

Condition or disease Intervention/treatment
Sick Sinus Syndrome Other: observation

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Study Type : Observational
Estimated Enrollment : 400 participants
Observational Model: Case Control
Study Start Date : February 2011

Resource links provided by the National Library of Medicine

Group/Cohort Intervention/treatment
sick sinus syndrome Other: observation


Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
The case group includes 200 patients and the control group includes 200 patients.

Inclusion Criteria:

  • sick sinus syndrome

Exclusion Criteria:

  • 1.Severe systemic disease.
  • 2.Acute coronary syndrome.
  • 3.bradycardia with reversible cause.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01310920

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Contact: Jan-Yow Chen, MD +886-4-22062121 ext 2311

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China Medical University Hospital Recruiting
Taiwan, Taiwan, 404
Contact: Jan-Yow Chen, M.D.    +886-4-22062121 ext 2311   
Principal Investigator: Jan-Yow Chen, MD         
Sponsors and Collaborators
China Medical University Hospital
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Principal Investigator: Jan-Yow Chen, M.D. China Medical University Hospital

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Responsible Party: Jan-Yow Chen, China Medical University hospital Identifier: NCT01310920     History of Changes
Other Study ID Numbers: DMR99-IRB-316
First Posted: March 9, 2011    Key Record Dates
Last Update Posted: March 9, 2011
Last Verified: March 2011
Additional relevant MeSH terms:
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Sick Sinus Syndrome
Pathologic Processes
Arrhythmia, Sinus
Arrhythmias, Cardiac
Heart Diseases
Cardiovascular Diseases
Heart Block
Cardiac Conduction System Disease