Search a Correlation Between Lp(a) Rate and TFPI Activity in Obese Patients With Chest Pain Like Angina
Atherosclerotic cardiovascular disease is a leading cause of mortality in our countries. Clinically, symptoms could be chest pain suggesting stable angina. Atherosclerosis is influenced by cardiovascular risk factors which obesity (Body Mass Index>30). Obesity is associated with an increase risk of cardiovascular complications.
Lipoprotein(a) is regarded as an independent risk factor for premature cardiovascular disease. Lp(a) is composed of low-density lipoprotein - like particle bound to glycoprotein molecule: apolipoprotein(a). Plasma levels are determinated to more than 90% by genetic factors (no significant influence of statin, weight, lifestyle factor: diet, exercise). Two study with few patients have found that aspirin lowers serum Lp(a) levels. Elevated Lp(a) is a risk factor for recurrent coronary events in obese patient.
Atherosclerosis is associated with imbalance of coagulation. TFPI (tissue factor pathway inhibitor) is the earliest inhibitor of the blood coagulation process, natural direct inhibitor of tissue factor. In-vitro, TFPI activity is inhibited by high Lp(a) .
The aim of this study is to research reverse association between Lp(a) and TFPI activity in obese patient with chest pain like stable angina suggesting atherosclerotic heart disease and effect of aspirin.
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Search a Correlation Between Lipoprotein(a) Rate and TFPI(Tissue Factor Pathway Inhibitor)Activity in Obese Patients With Chest Pain Like Angina|
- correlation between Lp(a) and TFPI activity [ Time Frame: day 1 ]Establish correlation between Lp(a) rate and TFPI activity in obese patients with chest pain like stable angina
- Correlation between Lp(a) and TFPI resistance [ Time Frame: day 1 ]Establish correlation between Lp(a) rate and TFPI resistance at inclusion and 1 month after aspirin treatment
- Correlation between lp(a) rate and TFPI activity [ Time Frame: 1 month ]Establish the correlation, 1 month after initiation of aspirin treatment, between lp(a) rate and TFPI activity
- thrombin generation [ Time Frame: day 1 ]describe thrombin generation with calibrated automated thrombinography technique in obese patient with chest pain like angina and hight Lp(a)rate
- Correlation between Lp(a) and TFPI resistance [ Time Frame: 1 month ]Establish correlation between Lp(a) rate and TFPI resistance at inclusion and 1 month after aspirin treatment
Biospecimen Retention: Samples Without DNA
|Study Start Date:||February 2011|
|Study Completion Date:||April 2014|
|Primary Completion Date:||February 2014 (Final data collection date for primary outcome measure)|
obese men with chest pain like angina
Other: blood sample
blood sample at inclusion and 1 month after inclusion
Please refer to this study by its ClinicalTrials.gov identifier: NCT01290770
|Service de cardiologie - CHG Feurs|
|Feurs, France, 42110|
|Service de cardiologie - CHG Firminy|
|Firminy, France, 42700|
|Service de cardiologie - CHU de Saint-Etienne|
|Saint-Etienne, France, 42055|
|Principal Investigator:||Brigitte TARDY, MD||CHU de Saint-Etienne|