New Echocardiographic Parameters for Assessment of Longitudinal Left Ventricular Function (LAX)

This study is currently recruiting participants. (see Contacts and Locations)
Verified July 2015 by Heidelberg University
Information provided by (Responsible Party):
Derliz Mereles, Heidelberg University Identifier:
First received: January 12, 2011
Last updated: July 6, 2015
Last verified: July 2015

Assessment of left ventricular systolic function is the most frequent indication for routine echocardiography. Qualitative eyeball method and biplane modified Simpson's rule, both measuring radial ventricular function, are the currently recommended methods to meet this challenge. Due to the complexity of the myocardial architecture, global left ventricular function also has longitudinal and torsional components.

The aim of this study is to evaluate new echocardiographic parameters for longitudinal left ventricular function. A special focus is set on strain imaging by speckle tracking, which is a relatively new technique. Patients with different cardiac pathologies (e. g. dilated cardiomyopathy, coronary artery disease, diastolic dysfunction) will be included and compared to healthy individuals.

Cardiovascular Pathology

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: New Echocardiographic Parameters for Assessment of Longitudinal Left Ventricular Function

Resource links provided by NLM:

Further study details as provided by Heidelberg University:

Primary Outcome Measures:
  • left ventricular longitudinal systolic strain (LV-LSS) in all patients [ Time Frame: 2 years ] [ Designated as safety issue: No ]
    left ventricular longitudinal systolic strain (LV-LSS) is measured in all patients by speckle tracking strain imaging

Secondary Outcome Measures:
  • mitral annular plane systolic excursion (MAPSE) in all patients [ Time Frame: 2 years ] [ Designated as safety issue: No ]
    MAPSE is measured by M-Mode echocardiography

  • mitral annular systolic velocity (MASV) in all patients [ Time Frame: 2 years ] [ Designated as safety issue: No ]
    MASV is derived from tissue doppler

  • diastolic left ventricular function in all patients [ Time Frame: 2 years ] [ Designated as safety issue: No ]
    Diastolic function is assesed by mitral inflow, mitral annulus velocity, pulmonary vein flow and velocity of flow progression.

  • pulmonary artery systolic pressure (PASP) in all patients [ Time Frame: 2 years ] [ Designated as safety issue: No ]
    PASP is derived from Tricuspid valve regurgitation velocity

  • left ventricular ejection fraction (LVEF) in all patients [ Time Frame: 2 years ] [ Designated as safety issue: No ]
    EF is measured by modified Simpson's rule (biplane)

Estimated Enrollment: 160
Study Start Date: January 2011
Estimated Study Completion Date: December 2021
Estimated Primary Completion Date: December 2015 (Final data collection date for primary outcome measure)
Healthy individuals without structural heart disease
Patients with coronary artery disease
Participants with dilated cardiomyopathy
Patients with hypertrophic non-obstructive cardiomyopathy
Patients with hypertrophic obstructive cardiomyopathy
Patients with restrictive cardiomyopathy
Patients with cardiac manifestation of amyloidosis
Patients with heart failure with preserved ejection fraction (diastolic heart failure)


Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Healthy individuals and patients with various cardiac pathologies, who undergo routine echocardiography at our department

Inclusion Criteria:

  • persons of 18 years and older who receive a transthoracic echocardiography at our department
  • written consent

Exclusion Criteria:

  • permanent pacemaker rhythm
  • moderate/severe valvular heart disease
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01275963

Contact: Derliz Mereles, M.D. +49622156 ext 8852
Contact: Matthias Aurich, M.D. +49622156 ext 38893

University of Heidelberg Recruiting
Heidelberg, Germany, 69120
Sponsors and Collaborators
Heidelberg University
Principal Investigator: Matthias Aurich, M.D. Heidelberg University
Principal Investigator: Derliz Mereles, M.D. Heidelberg University
  More Information

Additional Information:
No publications provided

Responsible Party: Derliz Mereles, Dr. Derliz Mereles, Heidelberg University Identifier: NCT01275963     History of Changes
Other Study ID Numbers: S-401/2010
Study First Received: January 12, 2011
Last Updated: July 6, 2015
Health Authority: Germany: Ethics Commission

Keywords provided by Heidelberg University:
Strain imaging
Ventricular Dysfunction
Longitudinal left ventricular function processed this record on November 27, 2015