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Dose-Dependent Effect of Early Antiplatelet Therapy in Acute Ischemic Stroke

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01273935
First Posted: January 11, 2011
Last Update Posted: January 11, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Ruhr University of Bochum
  Purpose
The aim of this study is to evaluate the low-response prevalence of early antiplatelet therapy and to test the influence of different aspirin dosages in patients with acute ischemic strokes (AIS).

Condition
Test the Efficacy of Antiplatelet Regimes in Acute Stroke

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Retrospective
Official Title: Dose-Dependent Effect of Early Antiplatelet Therapy in Acute Ischemic Stroke

Further study details as provided by Ruhr University of Bochum:

Primary Outcome Measures:
  • Result of platelet function test
    Aggregometry result of antiplatelet therapy


Enrollment: 400
Study Start Date: January 2010
Study Completion Date: December 2010
Groups/Cohorts
Responder
Responder versus Non-Responder as a result of platelet function test
Non-Responder
According to the result of platelet function test

Detailed Description:
Antiplatelet agents are important therapeutic options in treating patients with acute ischemic strokes to prevent recurrent ischemic events or death. The aim of this study was to evaluate the low-response prevalence of early antiplatelet therapy and the influence of different aspirin dosages in patients with acute ischemic strokes (AIS).
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients admitted to the stroke unit
Criteria

Inclusion Criteria:

  • suspected acute cerebrovascular ischemic events and patients who were admitted to the stroke unit where antiplatelet therapy was initiated

Exclusion Criteria:

  • severe liver disorders, current gastrointestinal disorders, congestive heart failure, life-threatening malignancies and a personal or family history of bleeding disorders
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01273935


Locations
Germany
Department of Neurology, St. Josef - Hospital, Ruhr-University
Bochum, NRW, Germany, D-44791
Sponsors and Collaborators
Ruhr University of Bochum
Investigators
Principal Investigator: Saskia H Meves, MD Department of Neurology, St. Josef - Hospital, Bochum, Germany
  More Information

Responsible Party: Medical Faculty Ruhr-University Bochum, Dekanat der Medizinischen Fakultät, Forschungsreferat - FoRUM
ClinicalTrials.gov Identifier: NCT01273935     History of Changes
Other Study ID Numbers: MevesASS01
First Submitted: January 10, 2011
First Posted: January 11, 2011
Last Update Posted: January 11, 2011
Last Verified: January 2010

Keywords provided by Ruhr University of Bochum:
Aspirin, Acute Cerebrovascular Ischemia, Platelet Function

Additional relevant MeSH terms:
Stroke
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases