Exercise and Health Intervention for Patients With Obsessive Compulsive Disorder (OCD)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01242735
Recruitment Status : Completed
First Posted : November 17, 2010
Last Update Posted : July 22, 2015
National Institute of Mental Health (NIMH)
Information provided by (Responsible Party):
Butler Hospital

Brief Summary:
The purpose of this study is to test the effect of a moderate-intensity aerobic exercise intervention for Obsessive Compulsive Disorder (OCD) patients interested in reducing symptoms. The investigators expect that this project will contribute much needed knowledge about the role that aerobic exercise can play in managing the effects of OCD. If moderate-intensity aerobic exercise is efficacious in helping individuals with OCD manage obsessions and compulsions, this will establish that aerobic exercise may be a valuable adjunct to other OCD treatments such as medication and therapy.

Condition or disease Intervention/treatment Phase
Obsessive Compulsive Disorder Behavioral: Aerobic exercise Behavioral: Health and Wellness Phase 2

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 56 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Testing the Efficacy of an Exercise Intervention for Patients With OCD
Study Start Date : November 2010
Actual Primary Completion Date : March 2015
Actual Study Completion Date : March 2015

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Experimental: Exercise
12-week moderate-intensity behavioral exercise intervention (AE)
Behavioral: Aerobic exercise
12-week moderate-intensity behavioral exercise intervention. Weekly sessions with an exercise physiologist who will also assign weekly exercise goals.

Active Comparator: Health and Wellness
12-week health and wellness education control (HEC)
Behavioral: Health and Wellness
12-week health and wellness education control. Weekly sessions about 12 different topics related to OCD, led by an OCD expert.

Primary Outcome Measures :
  1. Yale-Brown Obsessive Compulsive Scale (Y-BOCS; OCD symptomatology) [ Time Frame: 15 months ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  1. are between 18 and 65 years of age
  2. are sedentary, i.e. have not participated in regular aerobic physical exercise for at least 90 minutes per week during the past three months
  3. currently engaged in at least 12 weeks of stable dose pharmacotherapy and/or are currently engaged in cognitive-behavioral therapy for the past 13 weeks
  4. meet Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV) criteria for OCD as assessed by the Structured Clinical Interview for DSM Disorders, Patient Version (SCID-P)
  5. have Y-BOCS score greater than 16

Exclusion Criteria:

  1. DSM-IV diagnosis of substance abuse/dependence except for nicotine dependence
  2. DSM-IV diagnosis of anorexia or bulimia nervosa
  3. DSM-IV diagnosis of bipolar disorder
  4. history of psychotic disorder or current psychotic symptoms
  5. current suicidality or homicidality
  6. marked organic impairment
  7. physical or medical problems that would not allow for safe exercise participation
  8. current pregnancy or intent to become pregnant during the next 12 weeks

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01242735

United States, Rhode Island
Butler Hospital
Providence, Rhode Island, United States, 02906
Sponsors and Collaborators
Butler Hospital
National Institute of Mental Health (NIMH)
Principal Investigator: Ana M Abrantes, Ph.D. Butler Hospital

Responsible Party: Butler Hospital Identifier: NCT01242735     History of Changes
Other Study ID Numbers: 1006-001
1R01MH086513-01A1 ( U.S. NIH Grant/Contract )
First Posted: November 17, 2010    Key Record Dates
Last Update Posted: July 22, 2015
Last Verified: July 2015

Keywords provided by Butler Hospital:
Obsessive Compulsive Disorder
Aerobic Exercise

Additional relevant MeSH terms:
Compulsive Personality Disorder
Obsessive-Compulsive Disorder
Personality Disorders
Mental Disorders
Anxiety Disorders