Oral Malodour and Periodontal Disease-related Parameters
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|ClinicalTrials.gov Identifier: NCT01234948|
Recruitment Status : Completed
First Posted : November 4, 2010
Last Update Posted : November 4, 2010
|Condition or disease|
|Halitosis Periodontitis Gingivitis|
Show Detailed Description
|Study Type :||Observational|
|Actual Enrollment :||78 participants|
|Observational Model:||Case Control|
|Official Title:||Oral Malodour and Periodontal Disease-related Parameters. Clinical and Real-time PCR Findings|
|Study Start Date :||January 2008|
|Actual Primary Completion Date :||January 2009|
|Actual Study Completion Date :||September 2009|
Chronic periodontitis patients
Chronic periodontitis patients had at least one site per quadrant with clinical probing depth (CPD) > 5mm and radiographic evidence of bone loss
Generalised chronic gingivitis patients
Generalised chronic gingivitis patients presented with bleeding on probing (BOP) at > 30% of sites, CPDs < 4mm and no evidence of bone loss
Periodontally healthy subjects
Healthy subjects had < 10% sites with BOP and no sites with CPD > 3mm
- Halitosis presence [ Time Frame: At a single time point ]Subjects were designated as halitosis positive (+) when either the organoleptic score of the whole mouth air was two or more, and/or the readings of the Halimeter® exceeded 140 p.p.b.
- Tongue coating [ Time Frame: At a single time point ]
Assessment of tongue coating:
The Winkel Tongue Coating Index (Winkel et al., 2003) was visually determined by dividing the dorsum of the tongue into sextants. A score between zero and two was given to each sextant according to the amount of deposits and these scores were added giving a total ranging from zero to 12.
- Putative periodontal pathogens [ Time Frame: At a single time point ]A specimen was collected from the rear of the tongue dorsum for quantitative analysis of two putative periodontal pathogens, P. gingivalis and F. nucleatum, by real-time PCR.
- Periodontal clinical indices [ Time Frame: At a single time point ]plaque index, clinical probing depth, clinical attachment levels and bleeding on probing.
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01234948
|Dental School, Aristotle University|
|Thessaloniki, Greece, 54124|
|Study Chair:||Antonis Konstantinidis, Professor||Department of Preventive Dentistry, Periodontology and Biology of Implants, Dental School, Aristotle University of Thessaloniki, Greece|