Oral Malodour and Periodontal Disease-related Parameters
|ClinicalTrials.gov Identifier: NCT01234948|
Recruitment Status : Completed
First Posted : November 4, 2010
Last Update Posted : November 4, 2010
|Condition or disease|
|Halitosis Periodontitis Gingivitis|
Show Detailed Description
|Study Type :||Observational|
|Actual Enrollment :||78 participants|
|Observational Model:||Case Control|
|Official Title:||Oral Malodour and Periodontal Disease-related Parameters. Clinical and Real-time PCR Findings|
|Study Start Date :||January 2008|
|Actual Primary Completion Date :||January 2009|
|Actual Study Completion Date :||September 2009|
Chronic periodontitis patients
Chronic periodontitis patients had at least one site per quadrant with clinical probing depth (CPD) > 5mm and radiographic evidence of bone loss
Generalised chronic gingivitis patients
Generalised chronic gingivitis patients presented with bleeding on probing (BOP) at > 30% of sites, CPDs < 4mm and no evidence of bone loss
Periodontally healthy subjects
Healthy subjects had < 10% sites with BOP and no sites with CPD > 3mm
- Halitosis presence [ Time Frame: At a single time point ]Subjects were designated as halitosis positive (+) when either the organoleptic score of the whole mouth air was two or more, and/or the readings of the Halimeter® exceeded 140 p.p.b.
- Tongue coating [ Time Frame: At a single time point ]
Assessment of tongue coating:
The Winkel Tongue Coating Index (Winkel et al., 2003) was visually determined by dividing the dorsum of the tongue into sextants. A score between zero and two was given to each sextant according to the amount of deposits and these scores were added giving a total ranging from zero to 12.
- Putative periodontal pathogens [ Time Frame: At a single time point ]A specimen was collected from the rear of the tongue dorsum for quantitative analysis of two putative periodontal pathogens, P. gingivalis and F. nucleatum, by real-time PCR.
- Periodontal clinical indices [ Time Frame: At a single time point ]plaque index, clinical probing depth, clinical attachment levels and bleeding on probing.
Biospecimen Retention: Samples With DNA
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01234948
|Dental School, Aristotle University|
|Thessaloniki, Greece, 54124|
|Study Chair:||Antonis Konstantinidis, Professor||Department of Preventive Dentistry, Periodontology and Biology of Implants, Dental School, Aristotle University of Thessaloniki, Greece|