Exercise Training and Type 2 Diabetes
|ClinicalTrials.gov Identifier: NCT01234155|
Recruitment Status : Completed
First Posted : November 4, 2010
Last Update Posted : December 3, 2014
|Condition or disease||Intervention/treatment||Phase|
|Diabetes Mellitus, Type 2||Behavioral: Exercise Training - Interval Walking Behavioral: Exercise - Continuous Walking||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||32 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Study Start Date :||August 2010|
|Actual Primary Completion Date :||November 2012|
|Actual Study Completion Date :||November 2014|
|No Intervention: Control|
|Experimental: Exercise - Continuous Walking||
Behavioral: Exercise - Continuous Walking
Duration: 4 months. Exercise training sessions will be performed 3-5 days/week and will consist of walking for up to 60 minutes/day at 55% VO2max.
|Experimental: Exercise - Interval Walking||
Behavioral: Exercise Training - Interval Walking
Duration: 4 months. Exercise training sessions will be performed 3-5 days/week. Sessions will consist of walking for 3 minutes at 70% VO2max followed by 3 minutes at 40% VO2max for up to 60 minutes/day.
- Glycemic Control [ Time Frame: 0 and 4 months ]Fasting glucose, two-hour glucose during OGTT, and hemoglobin A1c will be measured.
- Beta-cell Function [ Time Frame: 0 and 4 months ]Glucose tolerance tests and hyperglycemic clamps combined with GLP-1 / GIP will be conducted. Glucose tracer kinetics and C-peptide deconvolution will be used to assess pancreatic function.
- Body Composition [ Time Frame: 0 and 4 months ]DXA and MRI will be used to assess changes in whole body and regional adiposity.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01234155
|Copenhagen, Denmark, 2100|
|Principal Investigator:||Thomas P Solomon, Ph.D.||Rigshospitalet, Denmark|
|Principal Investigator:||Kristian Karstoft, M.D.||Rigshospitalet, Denmark|