Biomarkers in Tissue Samples From Young Patients With Acute Myeloid Leukemia
|ClinicalTrials.gov Identifier: NCT01229956|
Recruitment Status : Completed
First Posted : October 28, 2010
Last Update Posted : May 19, 2016
RATIONALE: Studying samples of tissue from patients with cancer the in laboratory may help doctors identify and learn more about biomarkers related to cancer.
PURPOSE: This research study is studying biomarkers in tissue samples from young patients with acute myeloid leukemia.
|Condition or disease||Intervention/treatment|
|Leukemia||Genetic: DNA methylation analysis Genetic: gene expression analysis Genetic: microarray analysis Genetic: reverse transcriptase-polymerase chain reaction Other: laboratory biomarker analysis|
- To determine whether the pattern of global and TSG-specific promoter CpG island hypermethylation and gene silencing that we have shown characterizes MLL-rearranged (MLL-r) infant bilineage ALL is also characteristic of other subsets of MLL-r leukemia.
OUTLINE: Previously collected cryopreserved cells from diagnosis are analyzed for promoter methylation via HELP arrays, gene expression arrays, and RT-qPCR.
PROJECTED ACCRUAL: A total of 32 samples (8 from each of 4 biologically defined cohorts) will be analyzed.
|Study Type :||Observational|
|Estimated Enrollment :||32 participants|
|Official Title:||Promoter Methylation in MLL-Rearranged Childhood AML|
|Study Start Date :||November 2010|
|Primary Completion Date :||May 2016|
- Identification of differential patterns of promoter hypermethylation and gene expression in pairwise comparisons with other cohorts and normal controls
Biospecimen Retention: Samples With DNA
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01229956
|Principal Investigator:||Patrick N. Brown, MD||CHRISTUS Santa Rosa Cancer Center at CHRISTUS Santa Rosa Hospital - City Centre|