Epidemiology of Papillomavirus Infection (HPV) on Infected Women by Human Immunodeficience Virus (HIV) in West Indies and French Guiana. (HP2V-AG)
|ClinicalTrials.gov Identifier: NCT01226368|
Recruitment Status : Completed
First Posted : October 22, 2010
Last Update Posted : October 30, 2014
Cervical cancer is a public health problem. In term of frequency and mortality, it represents in Martinique the third localization the most frequently diagnosed and the fifth cause of death by cancer. Cervical cancer is recognized as viro-inducted. Human papillomavirus (HPV) is the etiologic agent, as a necessary but not sufficient cause, in the cancer genesis. It is estimated than about 70 to 80% of women have been or will be infected with an HPV in their genital life, the risks factors being those of the others sexually transmitted diseases (STD). Most of HPV infection are transient, by spontaneous clearance in a few months of the virus under episomal form.
Carcinogen risk is related to viral persistency which inducts the condition of cellular transformation.
Infection persistency and subsequent carcinogen risk depend of the genotype concerned and of the host immunitary response.
HIV infection is known to be associated with an higher prevalency of one or several infection with HPV-HR.
However, no data about HIV/HPV coinfection prevalency are available nowadays in French overseas department of South America whereas they are the most affected by HIV.
|Condition or disease||Intervention/treatment|
|1- Women 2- HIV Infection 3- Followed in West Indies and French Guiana for His Infection 4- Acceptance of the Use of Nadis® Medical Files||Other: Biological Sample collection|
|Study Type :||Observational|
|Actual Enrollment :||455 participants|
|Official Title:||Epidemiology of Papillomavirus Infection (HPV) on Infected Women by Human Immunodeficience Virus (HIV) in West Indies and French Guiana.|
|Study Start Date :||December 2010|
|Actual Primary Completion Date :||January 2011|
|Actual Study Completion Date :||March 2014|
Other: Biological Sample collection
- Presence of human papillomavirus [ Time Frame: 1 day ]Presence of human papillomavirus in women's cervical smear infected with HIV and followed in West Indies and French Guiana
- Characterization of Human papillomavirus genotypes [ Time Frame: 1 day ]Characterization of Human papillomavirus genotype found in women's cervical smear infected with HIV and followed in West Indies and French Guiana
- Presence and the severity of cervical injuries. [ Time Frame: 1 day ]
Biospecimen Retention: Samples With DNA
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01226368
|Centre Hospitalier Universitaire de Fort-de-France|
|Fort-de-France, Martinique, 97261|
|Study Director:||Sylvie ABEL, MD||University Hospital Center of Martinique|