We updated the design of this site on September 25th. Learn more.
Show more
ClinicalTrials.gov
ClinicalTrials.gov Menu

Liver Regeneration After Liver Resection

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified October 2010 by Nottingham University Hospitals NHS Trust.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT01220986
First Posted: October 14, 2010
Last Update Posted: October 14, 2010
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Nottingham University Hospitals NHS Trust
  Purpose
The aim of this study is to characterize Kupffer cell activity and activation of the innate immune response in the early phase of liver regeneration after right hepatectomy. The investigators hypothesise that liver regeneration after right hepatectomy in humans is associated with Kupffer cell activation and initiation of the innate immune response and that impaired liver regeneration, liver failure and sepsis following liver resection are associated with Kupffer cell dysfunction and an impaired innate immune response. The objectives for this study are to characterise Kupffer cell activity and the innate immune response in human liver before and after right hepatectomy.

Condition Intervention
Liver Diseases Hepatectomy Procedure: Liver biopsy

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: An Observational Study of Liver Regeneration After Right Hepatectomy: Understanding the Molecular Primers of Liver Regeneration

Further study details as provided by Nottingham University Hospitals NHS Trust:

Biospecimen Retention:   Samples With DNA
Liver tissue & serum

Estimated Enrollment: 20
Study Start Date: August 2010
Estimated Study Completion Date: August 2012
Estimated Primary Completion Date: December 2011 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Right hepatectomy
Intervals from inflow division.
Procedure: Liver biopsy
0, 30, 60, 90 min post inflow-division

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients undergoing right hepatectomy for colorectal liver metastases.
Criteria

Inclusion Criteria:

  • Patients requiring right hepatectomy for colorectal liver metastases

Exclusion Criteria:

  • Age >75, neoadjuvant chemotherapy, recurrent disease
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01220986


Contacts
Contact: John S Hammond, BM.BS PhD 01159249924 ext 70607 john.hammond@nottingham.ac.uk

Locations
United Kingdom
Nottingham University Hospitals NHS Trust, Queens Medical Centre Campus Recruiting
Nottingham, Nottinghamshire, United Kingdom, NG7 2UH
Sponsors and Collaborators
Nottingham University Hospitals NHS Trust
Investigators
Study Chair: Dileep N. Lobo, DM FRCS Reader in Surgery
  More Information

Responsible Party: John S. Hammond, Division of Surgery, NIHR Nottingham Digestive Diseases Centre BRU
ClinicalTrials.gov Identifier: NCT01220986     History of Changes
Other Study ID Numbers: NDDC10/H0403/32
First Submitted: October 13, 2010
First Posted: October 14, 2010
Last Update Posted: October 14, 2010
Last Verified: October 2010

Keywords provided by Nottingham University Hospitals NHS Trust:
Liver regeneration
Innate immune response

Additional relevant MeSH terms:
Liver Diseases
Digestive System Diseases
Liver Extracts
Hematinics


To Top