We updated the design of this site on December 18, 2017. Learn more.
ClinicalTrials.gov Menu
IMPORTANT: Due to the lapse in government funding, the information on this web site may not be up to date, transactions submitted via the web site may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

Liver Regeneration After Liver Resection

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT01220986
Recruitment Status : Unknown
Verified October 2010 by Nottingham University Hospitals NHS Trust.
Recruitment status was:  Recruiting
First Posted : October 14, 2010
Last Update Posted : October 14, 2010
Information provided by:

Study Description
Brief Summary:
The aim of this study is to characterize Kupffer cell activity and activation of the innate immune response in the early phase of liver regeneration after right hepatectomy. The investigators hypothesise that liver regeneration after right hepatectomy in humans is associated with Kupffer cell activation and initiation of the innate immune response and that impaired liver regeneration, liver failure and sepsis following liver resection are associated with Kupffer cell dysfunction and an impaired innate immune response. The objectives for this study are to characterise Kupffer cell activity and the innate immune response in human liver before and after right hepatectomy.

Condition or disease Intervention/treatment
Liver Diseases Hepatectomy Procedure: Liver biopsy

Study Design

Study Type : Observational
Estimated Enrollment : 20 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: An Observational Study of Liver Regeneration After Right Hepatectomy: Understanding the Molecular Primers of Liver Regeneration
Study Start Date : August 2010
Estimated Primary Completion Date : December 2011
Estimated Study Completion Date : August 2012
Groups and Cohorts

Group/Cohort Intervention/treatment
Right hepatectomy
Intervals from inflow division.
Procedure: Liver biopsy
0, 30, 60, 90 min post inflow-division

Outcome Measures

Biospecimen Retention:   Samples With DNA
Liver tissue & serum

Eligibility Criteria

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients undergoing right hepatectomy for colorectal liver metastases.

Inclusion Criteria:

  • Patients requiring right hepatectomy for colorectal liver metastases

Exclusion Criteria:

  • Age >75, neoadjuvant chemotherapy, recurrent disease
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01220986

Contact: John S Hammond, BM.BS PhD 01159249924 ext 70607 john.hammond@nottingham.ac.uk

United Kingdom
Nottingham University Hospitals NHS Trust, Queens Medical Centre Campus Recruiting
Nottingham, Nottinghamshire, United Kingdom, NG7 2UH
Sponsors and Collaborators
Nottingham University Hospitals NHS Trust
Study Chair: Dileep N. Lobo, DM FRCS Reader in Surgery
More Information

Responsible Party: John S. Hammond, Division of Surgery, NIHR Nottingham Digestive Diseases Centre BRU
ClinicalTrials.gov Identifier: NCT01220986     History of Changes
Other Study ID Numbers: NDDC10/H0403/32
First Posted: October 14, 2010    Key Record Dates
Last Update Posted: October 14, 2010
Last Verified: October 2010

Keywords provided by Nottingham University Hospitals NHS Trust:
Liver regeneration
Innate immune response

Additional relevant MeSH terms:
Liver Diseases
Digestive System Diseases
Liver Extracts