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Effect of Ambient Light on the Parameters of the Pupillary Light Reflex

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ClinicalTrials.gov Identifier: NCT01207817
Recruitment Status : Completed
First Posted : September 23, 2010
Last Update Posted : September 23, 2010
Sponsor:
Information provided by:
Rutgers, The State University of New Jersey

Brief Summary:
The purpose of this study is to determine the effects of varying luminescent levels on the pupillary response.

Condition or disease Intervention/treatment
Healthy Volunteers Other: Pupillometry

Detailed Description:
Evaluation of the pupillary response is an underemphasized aspect of the assessment of visual function. The pupillary light reflex is one of the few objective indicators of afferent input from the retina and optic nerve. Since the pupillary light reflex is processed through the retina, it may be used to assess visual integrity (1). Pupillometry is a reliable technology capable of providing repetitive data on quantitative pupillary function in states of health and disease (2). Amplitude, latency, maximum constriction velocity, mean constriction velocity, and dilation velocity are measured using the Neuroleptics pupillometer. The effects of varying levels of ambient light on these parameters of the pupillary response have not been extensively studied. The purpose of this investigation is to determine the effects of varying luminescent levels on the pupillary response.

Study Type : Observational
Estimated Enrollment : 30 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: Effect of Ambient Light on the Parameters of the Pupillary Light Reflex
Study Start Date : September 2009
Actual Primary Completion Date : February 2010
Actual Study Completion Date : February 2010

Group/Cohort Intervention/treatment
no condition
no condition - healthy volunteers
Other: Pupillometry
Pupillometry readings will be taken at low, intermediate and high ambient light




Primary Outcome Measures :
  1. pupillary light reflex: amplitude, latency, maximum constriction velocity, mean constriction velocity and dilation velocity during different levels of ambient light [ Time Frame: Pupillometry readings will be taken at 3 potential light readings low light, intermediate light and high ambient light. A total of 48 readings will be done. All parameters will be done at one sitting and will take approximately 45 minutes to complete. ]


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Ages Eligible for Study:   18 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Healthy volinteers
Criteria

Inclusion Criteria:

  • healthy volunteers

Exclusion Criteria:

  • recent bout of conjunctivitis or infection in the eye recent eye surgery seizure disorder unable to lie flat for 30 minutes known history of eye disease which cannot be corrected with lenses

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01207817


Locations
United States, New Jersey
UMDNJ-University Hospital
Newark, New Jersey, United States, 07101
Sponsors and Collaborators
University of Medicine and Dentistry of New Jersey
Investigators
Principal Investigator: Lawrence W Chinn, MD UMDNJ-NJMS

Responsible Party: Lawrence Chin, MD, UMDNJ
ClinicalTrials.gov Identifier: NCT01207817     History of Changes
Other Study ID Numbers: 0120090181
First Posted: September 23, 2010    Key Record Dates
Last Update Posted: September 23, 2010
Last Verified: September 2010

Keywords provided by Rutgers, The State University of New Jersey:
a light flash in each eye for a total of 48 measurements