Assessment of Transcutaneous Oxygen Tension/Oxygen Challenge Test in Intensive Care Unit (ICU) Patients (ICUPtO2OCT)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT01174966|
Recruitment Status : Unknown
Verified August 2010 by Peking Union Medical College Hospital.
Recruitment status was: Recruiting
First Posted : August 4, 2010
Last Update Posted : August 4, 2010
The lack of subcutaneous partial pressure of oxygen (PO2) rise in response to high fraction of inspired oxygen (FiO2), called the "oxygen challenge test (OCT)", was associated with higher morbidity and mortality in human subjects. Patients had negative O2 challenge test results, indicating that flow-dependent O2 consumption might have been present. Recent reports using the noninvasive transcutaneous PO2 (PtO2) and transcutaneous partial pressure of carbon dioxide probes have observed a relationship between low oxygen challenge test values to mortality and organ failure. The OCT values provides an accessible noninvasive method of detecting early shock.
To date,these studies of OCT in the ICU patients are rarely. No one has quantified OCT to CI, DO2I、ScvO2.
This study explored:
- relationship between patient factors, hemodynamic variables, PtO2, and OCT to mortality;
- relationship between PtO2 index, tissue oxygen index, oxygen Challenge index to CI, DO2, ScvO2.
|Condition or disease|
PtO2 index = PtO2/PaO2；tissue oxygen index=PtO2/FiO2；
5min OCT value = challenged 5minPtO2 - PtO2baseline；
10min OCT value= challenged 10minPtO2- PtO2baseline；
oxygen challenge index = （10minPtO2- PtO2baseline）/(10minPaO2-PaO2baseline)
|Study Type :||Observational|
|Estimated Enrollment :||60 participants|
|Official Title:||Assessment of Transcutaneous Oxygen Tension and Oxygen Challenge Test in Adult Intensive Care Patients|
|Study Start Date :||September 2009|
|Estimated Primary Completion Date :||October 2010|
|Estimated Study Completion Date :||October 2010|
- ICU mortality [ Time Frame: 28 day after enrollmented ]
- hospital mortality [ Time Frame: 28 day after enrollmented ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01174966
|Contact: dawei liu, MDemail@example.com|
|Contact: huaiwu firstname.lastname@example.org|
|Peking Union Medical College Hospital||Recruiting|
|Beijing, Beijing, China, 100730|
|Contact: dawei liu, MD 010-65296091 email@example.com|
|Contact: huaiwu he 010-65296094 firstname.lastname@example.org|
|Sub-Investigator: huaiwu he|
|Principal Investigator:||dawei liu, MD||Peking Union Medical College Hospital|