Optimal Concentration of Dermatophagoides Pteronyssinus (Dp) Allergen Extract for Skin Prick Test (SPT) of Thai Population (DSPT)
Recruitment status was: Recruiting
Rhinitis, Allergic, Perennial
Rhinitis, Allergic, Seasonal
Skin Prick Test
|Study Design:||Observational Model: Case Control
Time Perspective: Cross-Sectional
|Official Title:||Optimal Concentration of Allergen Extract of Dermatophagoides Pteronyssinus to be Used in Diagnostic Allergy Skin Prick Test Among Thai Population|
- appropriate concentration of diagnostic reagent of house dust mite (Dp) [ Time Frame: 15 minutes ] [ Designated as safety issue: No ]to determine appropriate dilutional concentration of diagnostic reagent of house dust mite (Dp) that has high sensitivity and positive predictive value and wheal size not more than 10 mm. to be used in diagnosis allergic rhinitis in Thai population by skin prick test.
- false positive rates of various dilutions of diagnostic reagent (house dust mite: Dp) that be used in skin prick test in Thai healthy population [ Time Frame: 15 minutes ] [ Designated as safety issue: No ]
- false negative rates of various dilutions of diagnostic reagent (house dust mite: Dp) that be used for diagnosis allergic rhinitis in Thai population by skin prick test [ Time Frame: 15 minutes ] [ Designated as safety issue: No ]
|Study Start Date:||June 2010|
|Estimated Primary Completion Date:||December 2010 (Final data collection date for primary outcome measure)|
|healthy subjects no symptoms|
|allergic rhinitis patient|
The current allergy diagnostic reagent of house dust mites marketed in the USA is at 10,000 AU/ml. This is based on the IDEAL50 concept put forth by Turkeltaub et al, almost 3 decades ago. Such concentration has been shown to give large degree of false positives even in the US population.
In Thailand, it was anecdotally observed that at such concentration, sizes of positive tests among atopic subjects were quite large and could lead to discomfort and a possible anaphylaxis in certain allergic individuals. Moreover, up to 40% of normal individuals could give positive reaction to this concentration.
It is therefore desirable to reexamine the appropriate concentration of diagnostic reagent of house dust mites among the Thai population and will be the main objective of this research.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01172613
|Bangkok, Thailand, 10700|
|Principal Investigator:||Professor Pakit Vichyanond, MD||Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University|