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Creatine Supplementation and Cognition

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01164020
First Posted: July 16, 2010
Last Update Posted: January 18, 2013
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Bruno Gualano, University of Sao Paulo
  Purpose
Resistance training as well as creatine supplementation may be beneficial for cognitive function, such as memory and attention. Therefore, the investigators speculate that resistance training combined with creatine supplementation would promote additive benefits on cognitive function in elderly women.

Condition Intervention
Cognition Aging Dietary Supplement: creatine supplementation Other: Placebo (Dextrose) Other: Resistance training

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Prevention

Resource links provided by NLM:


Further study details as provided by Bruno Gualano, University of Sao Paulo:

Primary Outcome Measures:
  • cognitive function [ Time Frame: six months ]

Secondary Outcome Measures:
  • physical capacity [ Time Frame: six months ]
    muscle strength and function


Enrollment: 56
Study Start Date: August 2010
Study Completion Date: December 2012
Primary Completion Date: December 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Placebo Comparator: placebo control
this only receives placebo (dextrose)
Other: Placebo (Dextrose)
20g/d for 7 days followed by 5g/d for 23 weeks
Experimental: placebo and exercise
this is trained and receives placebo
Other: Placebo (Dextrose)
20g/d for 7 days followed by 5g/d for 23 weeks
Other: Resistance training
resistance training twice a week for 24 weeks
Experimental: creatine supplementation
this is non-exercise trained and receives creatine supplementation
Dietary Supplement: creatine supplementation
20g/d for 7 days followed by 5g/d for 23 weeks
Experimental: Creatine and Exercise
this is exercised trained and receives creatine supplementation
Dietary Supplement: creatine supplementation
20g/d for 7 days followed by 5g/d for 23 weeks
Other: Resistance training
resistance training twice a week for 24 weeks

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   60 Years and older   (Adult, Senior)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • women older than 60 years old

Exclusion Criteria:

  • cardiovascular diseases or muscular disturbances precluding exercise training
  • drugs affecting the cognition
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01164020


Locations
Brazil
School of Medicine - Division of Rheumatology
São Paulo, Brazil, 05508-030
Sponsors and Collaborators
University of Sao Paulo
Investigators
Principal Investigator: Bruno Gualano, PhD University of Sao Paulo
Principal Investigator: Antonio H Lancha Junior, PhD University of Sao Paulo
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Bruno Gualano, Principal Investigator, University of Sao Paulo
ClinicalTrials.gov Identifier: NCT01164020     History of Changes
Other Study ID Numbers: Creatine and Cognition
First Submitted: July 15, 2010
First Posted: July 16, 2010
Last Update Posted: January 18, 2013
Last Verified: January 2013

Keywords provided by Bruno Gualano, University of Sao Paulo:
cognition
supplementation creatine
resistance training
aging