Hyperuricemia on Hypertension and Metabolic Syndrome
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|ClinicalTrials.gov Identifier: NCT01157936|
Recruitment Status : Completed
First Posted : July 8, 2010
Last Update Posted : July 24, 2014
|Condition or disease||Intervention/treatment||Phase|
|Systolic and Diastolic Blood Pressure Levels Uric Acid Levels Metabolic Syndrome Parameters Hepatic Enzymes||Drug: Allopurinol Other: placebo||Phase 2|
Elevated consumption of high fructose corn syrup has lead to an increase of 30% of fructose intake since the last 20 years. Important data supporting this fact can be reflected on incidence and prevalence of Metabolic syndrome and hyperuricemia.
A peculiar effect of fructose intake demonstrated in animal models is the development of elevated uric acid levels; also some studies have found a clear association between hyperuricemia as an important risk factor for hypertension, diabetes mellitus, chronic kidney disease and metabolic syndrome.
Taking into account the existing evidence, our clinical research team presents this protocol as a way to evaluate the effect of uric acid treatment and its relation with Fructose consumption, metabolic syndrome parameters, hyperuricemia and risk of hypertension.
Confirming evidence with clinical basis may be the initial strategy to create primary prevention programs to control this health problems affecting Mexican Population.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||40 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|
|Official Title:||Effect of Hyperuricemia Treatment on Hypertension and Metabolic Syndrome|
|Study Start Date :||July 2010|
|Actual Primary Completion Date :||February 2011|
|Actual Study Completion Date :||August 2011|
|Active Comparator: Allopurinol treatment||
Other Name: xanthine oxidase inhibitor
|Placebo Comparator: Placebo||
- Effect of hyperuricemia treatment on systemic blood pressure [ Time Frame: 14 weeks ]participants will be randomized to a 4 week placebo versus alopurinol treatment followed by a wash out period. After crossover them, they will receive the complementary pharmacological intervention for another 4 weeks.
- Effect of hyperuricemia treatment on metabolic syndrome parameters [ Time Frame: 14 weeks ]baseline and final laboratory samples during pre and post crossover periods will include metabolic syndrome measurements (triglycerides, cholesterol, glucose and abdominal perimeter).
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01157936
|Insituto Nacional de Cardiología Ignacio Chávez|
|Mexico, Mexico, 14080|
|Principal Investigator:||Magdalena Madero, MD||Instituto Nacional de Cardiología Ignacio Chávez|