Deep Low-Frequency Repetitive Transcranial Magnetic Stimulation for Cessation of Pathological Gambling
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ClinicalTrials.gov Identifier: NCT01154712 |
Recruitment Status
: Unknown
Verified January 2010 by BeerYaakov Mental Health Center.
Recruitment status was: Recruiting
First Posted
: July 1, 2010
Last Update Posted
: July 14, 2010
|
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Pathological Gambling | Device: Real Deep TMS Device: Sham Deep TMS | Phase 1 |

Study Type : | Interventional (Clinical Trial) |
Estimated Enrollment : | 40 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Double (Participant, Outcomes Assessor) |
Primary Purpose: | Treatment |
Official Title: | Deep Low-Frequency Repetitive Transcranial Magnetic Stimulation for Cessation of Pathological Gambling |
Study Start Date : | June 2010 |
Estimated Primary Completion Date : | June 2012 |
Estimated Study Completion Date : | June 2012 |

Arm | Intervention/treatment |
---|---|
Active Comparator: Real Deep TMS
Stimulation parameters : Dorso lateral prefrontal cortex,1HZ,600 pulses per session,15 sessions
|
Device: Real Deep TMS
Stimulation parameters : Dorso lateral prefrontal cortex,1HZ,600 pulses per session,15 sessions
|
Sham Comparator: Sham Deep TMS
Stimulation parameters : Dorso lateral prefrontal cortex,1HZ,600 pulses per session,15 sessions
|
Device: Sham Deep TMS
Stimulation parameters : Dorso lateral prefrontal cortex,1HZ,600 pulses per session,15 sessions
|
- SOGS (South Oaks Gambling Screen) [ Time Frame: 45 days ]The South Oaks Gambling Screen is a 20-item questionnaire based on Diagnostic and Statistical Manual of Mental Disorders, Third Edition (DSM-III) criteria for pathological gambling.
- Dannon Ainhold Gambling Scale [ Time Frame: 45 days ]A scale for assessment of pathological gambling
- visual analogue scale [ Time Frame: 45 Days ]An instrument for assessment of desire to indulge in gambling
- Hamilton Depression 24 items [ Time Frame: 45 Days ]Depression assessment scale
- Hamilton Anxiety scale [ Time Frame: 45 days ]Anxiety assessment scale
- Yale-Brown Obsessive Compulsive Scale (Y-BOCS) [ Time Frame: 45 days ]A scale for assessment of compulsions and obsessions
- Clinical Global Impression Improvement (CGI-I) [ Time Frame: 45 days ]A scale for assessment of global clinical improvement
- Social Adaptational Scale(SAS) [ Time Frame: 45 days ]A scale for assessment of Social Adaptation

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Ages Eligible for Study: | 18 Years to 65 Years (Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Pathological gambling according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR)
Exclusion Criteria:
- History of a primary major psychiatric or cognitive disorder according to DSM IV apart from Pathological gambling.
- Current alcohol or other substance abuse or dependence.
- Alcohol or other substance abuse or dependence during the last 12 months before recruitment.
- History of or evidence of significant brain malformation or neoplasm, head injury, cerebral vascular events, neurodegenerative disorder affecting the brain or prior brain surgery.
- Significant neurological co-morbidity.
- psychiatric co-morbidity.
- psychotropic medications.
- Severe somatic co morbidity.
- Cardiac pace makers, other electronic implants, intracranial metallic particles.
- History of seizures or epileptiform activity.
- Pregnancy and lactation.
- Patients who cannot communicate reliably with the investigator or who are not likely to cope with the requirements of the experiment.
- Patients unwilling or unable to give written informed consent.
- Patients with a high risk for severe violence or suicidality as assessed during the screening interview.
- Participation in a clinical trial within the last 30 days before the beginning of this clinical trial or similar participation in another clinical trial.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01154712
Contact: Oded Rosenberg, M.D. | 97289284293 | odedaruna@gmail.com | |
Contact: Pinhas Dannon, M.D. | 97289258396 | pinhas.dannon@beerness.health.gov.il |
Israel | |
Beer Yaakov Mental Health Center | Recruiting |
Beer Yaakov, Hashfela, Israel, 70350 | |
Contact: Oded Rosenberg, MD 97289284293 odedaruna@gmail.com | |
Contact: Pinhas Dannon, MD 97289258396 pinhas.dannon@beerness.health.gov.il |
Study Chair: | Oded Rosenberg, MD | Beer Yaakov Mental Health Center | |
Principal Investigator: | Pinhas Dannon, MD | Beer Yaakov Mental Health Center |
Responsible Party: | Dr. Oded Rosenberg, Beer Ya'acov mental health institue |
ClinicalTrials.gov Identifier: | NCT01154712 History of Changes |
Other Study ID Numbers: |
244 |
First Posted: | July 1, 2010 Key Record Dates |
Last Update Posted: | July 14, 2010 |
Last Verified: | January 2010 |
Keywords provided by BeerYaakov Mental Health Center:
Gambling Deep TMS addiction Brain stimulation |
Additional relevant MeSH terms:
Gambling Disruptive, Impulse Control, and Conduct Disorders Mental Disorders |