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Cerebral Oxygen, Blood Flow and Ammonia Uptake in Patients With Cirrhosis and an Acute Episode of Hepatic Encephalopathy (HE)

This study has been completed.
Information provided by (Responsible Party):
University of Aarhus Identifier:
First received: June 25, 2010
Last updated: June 18, 2012
Last verified: June 2012
We wish to study patients with liver cirrhosis during and 2 weeks after an acute episode of liver coma (hepatic encephalopathy). By means of Positron Emission Tomography we investigate; brain blood flow, brain ammonia uptake and brain oxygen consumption. We hypothesize that blood flow an oxygen consumption is diminished and ammonia uptake increased during an acute episode of hepatic encephalopathy.

Liver Cirrhosis
Hepatic Encephalopathy

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Cerebral Oxygen, Blood Flow and Ammonia Uptake in Patients With Cirrhosis and an Acute Episode of HE

Resource links provided by NLM:

Further study details as provided by University of Aarhus:

Enrollment: 10
Study Start Date: August 2010
Study Completion Date: August 2011
Primary Completion Date: August 2011 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
patients with hepatic encephalopathy

Inclusion Criteria:

  • patients with an acute episode of hepatic encephalopathy

Exclusion Criteria:

  • previous stroke
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Please refer to this study by its identifier: NCT01151475

Gitte Dam
Aarhus, Denmark, 8000
Sponsors and Collaborators
University of Aarhus
  More Information

Responsible Party: University of Aarhus Identifier: NCT01151475     History of Changes
Other Study ID Numbers: 24698
Study First Received: June 25, 2010
Last Updated: June 18, 2012

Keywords provided by University of Aarhus:
liver cirrhosis
hepatic encephalopathy
cerebral blood flow

Additional relevant MeSH terms:
Liver Cirrhosis
Brain Diseases
Hepatic Encephalopathy
Pathologic Processes
Liver Diseases
Digestive System Diseases
Central Nervous System Diseases
Nervous System Diseases
Liver Failure
Hepatic Insufficiency
Brain Diseases, Metabolic
Metabolic Diseases processed this record on April 28, 2017