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Cerebral Oxygen, Blood Flow and Ammonia Uptake in Patients With Cirrhosis and an Acute Episode of Hepatic Encephalopathy (HE)

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01151475
First Posted: June 28, 2010
Last Update Posted: June 19, 2012
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Information provided by (Responsible Party):
University of Aarhus
  Purpose
We wish to study patients with liver cirrhosis during and 2 weeks after an acute episode of liver coma (hepatic encephalopathy). By means of Positron Emission Tomography we investigate; brain blood flow, brain ammonia uptake and brain oxygen consumption. We hypothesize that blood flow an oxygen consumption is diminished and ammonia uptake increased during an acute episode of hepatic encephalopathy.

Condition
Liver Cirrhosis Hepatic Encephalopathy

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Cerebral Oxygen, Blood Flow and Ammonia Uptake in Patients With Cirrhosis and an Acute Episode of HE

Resource links provided by NLM:


Further study details as provided by University of Aarhus:

Enrollment: 10
Study Start Date: August 2010
Study Completion Date: August 2011
Primary Completion Date: August 2011 (Final data collection date for primary outcome measure)
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
patients with hepatic encephalopathy
Criteria

Inclusion Criteria:

  • patients with an acute episode of hepatic encephalopathy

Exclusion Criteria:

  • previous stroke
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01151475


Locations
Denmark
Gitte Dam
Aarhus, Denmark, 8000
Sponsors and Collaborators
University of Aarhus
  More Information

Responsible Party: University of Aarhus
ClinicalTrials.gov Identifier: NCT01151475     History of Changes
Other Study ID Numbers: 24698
First Submitted: June 25, 2010
First Posted: June 28, 2010
Last Update Posted: June 19, 2012
Last Verified: June 2012

Keywords provided by University of Aarhus:
liver cirrhosis
hepatic encephalopathy
ammonia
cerebral blood flow

Additional relevant MeSH terms:
Fibrosis
Liver Cirrhosis
Brain Diseases
Hepatic Encephalopathy
Pathologic Processes
Liver Diseases
Digestive System Diseases
Central Nervous System Diseases
Nervous System Diseases
Liver Failure
Hepatic Insufficiency
Brain Diseases, Metabolic
Metabolic Diseases