Biomarkers in Samples From Patients With Follicular Lymphoma Treated With Rituximab
Recruitment status was: Not yet recruiting
RATIONALE: Studying the effects of rituximab in blood and tumor tissue samples from patients with cancer in the laboratory may help doctors learn more about the effects of rituximab on cancer cells. It may also help doctors identify biomarkers related to cancer.
PURPOSE: This research study is studying biomarkers in samples from patients with follicular lymphoma treated with rituximab.
Genetic: gene expression analysis
Genetic: microarray analysis
Genetic: polymerase chain reaction
Genetic: polymorphism analysis
Other: immunohistochemistry staining method
Other: laboratory biomarker analysis
|Official Title:||Identification of Biomarkers Predicting Responsiveness to Rituximab in Follicular Lymphoma|
- Correlation between FcγR polymorphisms and rituximab response, response duration, and time to resistance [ Designated as safety issue: No ]
- Identification of gene expression profiles correlated with rituximab response, response duration, and time to resistance [ Designated as safety issue: No ]
- Follicular lymphoma microenvironment predictive of rituximab initial response and duration of response [ Designated as safety issue: No ]
|Study Start Date:||August 2010|
|Estimated Primary Completion Date:||September 2010 (Final data collection date for primary outcome measure)|
- Correlate immunoglobulin Fc receptor (FcγR) polymorphisms with response, response duration, and time to resistance in samples from patients with follicular lymphoma (FL) treated with single-agent rituximab on ECOG-E4402.
- Identify gene expression profiles that correlate with response, response duration, and time to rituximab resistance in these patients.
- Determine whether the FL microenvironment is predictive of initial response and duration of response to rituximab.
OUTLINE: DNA and RNA from banked peripheral blood mononuclear cells (PBMCs) and formalin-fixed paraffin-embedded (FFPE) tumor samples are analyzed for immunoglobulin-receptor polymorphism, gene expression profile, and follicular lymphoma microenvironment by real-time PCR, microarray hybridization, and IHC.
PROJECTED ACCRUAL: A total of 259 PBMC samples and 300 FFPE blocks will be accrued for this study.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01150643
|Principal Investigator:||Brad S. Kahl, MD||University of Wisconsin, Madison|