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Correlation Between Circulating Resistin and Vascular Inflammation Measured by 18F-fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) (18FDG-PET)

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01150019
First Posted: June 24, 2010
Last Update Posted: July 8, 2010
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Korea University
  Purpose

Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis.Resistin was shown to induce vascular endothelial dysfunction and vascular smooth muscle cell proliferation.

18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.Therefore, the purpose of the study is to demonstrate the correlation between circulating resistin and vascular inflammation detected by 18FDG-PET in obese persons.


Condition Intervention
Atherosclerosis Other: Cross sectional study

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Correlation Between Circulating Resistin and Vascular Inflammation Measured by 18FDG-PET in Obese Person

Resource links provided by NLM:


Further study details as provided by Korea University:

Primary Outcome Measures:
  • Vascular inflammation in carotid arterial wall represented as the target-to-background ratio (TBR) using FDG-PET [ Time Frame: 12 weeks ]

Secondary Outcome Measures:
  • Circulating serum adiponectin levels [ Time Frame: 12 weeks ]
  • carotid intima-media thickness levels measured using ultrasonography [ Time Frame: 12 weeks ]
  • Circulating serum resistin levels [ Time Frame: 12 weeks ]

Biospecimen Retention:   Samples Without DNA
Plasma, whole blood, serum

Enrollment: 120
Study Start Date: April 2010
Study Completion Date: June 2010
Primary Completion Date: June 2010 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Obese Group Other: Cross sectional study
This is not intervention study. The purpose of the study is to examine the relationship between various adipokine levels and PET imaging at the cross section setting
Non Obese Group Other: Cross sectional study
This is not intervention study. The purpose of the study is to examine the relationship between various adipokine levels and PET imaging at the cross section setting

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Healthy participats who underwent a medical health check in the health promotion center in Korea Guro University
Criteria

Inclusion Criteria:

  • Healthy volunteers for visiting routine medical check in our clinic

Exclusion Criteria:

  • History of cardiovascular disease (myocardial infarction, unstable angina,stroke, or cardiovascular revascularization)
  • Diabetes
  • Hypertension
  • Malignancy
  • Severe renal or hepatic disease
  • Subjects taking medications that might affect inflammation such as non-steroidal anti-inflammatory drugs (NSAIDs) and statin
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01150019


Locations
Korea, Republic of
Hae Yoon Choi
Seoul, Korea, Republic of, 152-703
Sponsors and Collaborators
Korea University
Investigators
Principal Investigator: Kyung Mook Choi, MD.PhD Korea University
  More Information

Responsible Party: Kyung Mook Choi, Korea University
ClinicalTrials.gov Identifier: NCT01150019     History of Changes
Other Study ID Numbers: PET_Resistin
First Submitted: June 9, 2010
First Posted: June 24, 2010
Last Update Posted: July 8, 2010
Last Verified: April 2010

Keywords provided by Korea University:
atherosclerosis
vascular inflammation
resistin
adiponectin
18FDG-PET

Additional relevant MeSH terms:
Inflammation
Atherosclerosis
Pathologic Processes
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases
Cardiovascular Diseases
Fluorodeoxyglucose F18
Radiopharmaceuticals
Molecular Mechanisms of Pharmacological Action


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