NADPH Oxidase Polymorphisms in Obstructive Sleep Apnea Syndrome (OSAS)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01141829
Recruitment Status : Unknown
Verified January 2010 by Sociedad Española de Neumología y Cirugía Torácica.
Recruitment status was:  Recruiting
First Posted : June 11, 2010
Last Update Posted : June 11, 2010
Spanish Research Center for Respiratory Diseases
Information provided by:
Sociedad Española de Neumología y Cirugía Torácica

Brief Summary:
Obstructive Sleep Apnea (OSA) is associated with increased oxidative stress. The major sources of Reactive Oxygen Species (ROS) in the vasculature are the NADPH oxidases. Several polymorphisms related to NADPH oxidase expression or NADPH oxidase activity has been identified. The investigators are going to compare the distribution of the allelic frequencies of A-930G and C242T polymorphisms and their possible relationship with the levels of 8-isoprostanes as a marker of oxidative stress in patients with OSA and in a control group without OSA.

Condition or disease
Sleep Apnea Syndrome Oxidative Stress Single Nucleotide Polymorphism

Detailed Description:
DESIGN: CASE-CONTROL STUDY METHODS: We are going to determine the A-930G and C242T p22phox genotypes in patients with OSA and healthy subjects recruited from sleep unit of Son Dureta University Hospital, (Palma de Mallorca, Spain). 8-Isoprostane is going to be measured as an oxidative stress marker with an 8-isoprostane EIA kit (Cayman Chemicals Company, USA) in plasma samples.

Study Type : Observational
Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: NADPH Oxidase p22phox Polymorphisms and Oxidative Stress in Patients With Obstructive Sleep Apnea

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Sleep Apnea

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
patients with OSAS defined by an apnea hypopnea index (AHI)>10 h-1 will be included in the study along with control subjects without OSAS. Participants were consequently studied at the sleep unit of Hospital Universitario Son Dureta, (Palma de Mallorca, Spain).

Inclusion Criteria:Polyysomnografic study with Apnoea/Hypoapnoea Index higher to 10 in patients and lower in controls.

Exclusion Criteria:

  • chronic obstructive pulmonary disease, liver cirrhosis, thyroid dysfunction, rheumatoid arthritis, chronic renal failure and/or psychiatric disorders.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01141829

Contact: Mónica de La Peña, MD 0034971175112

Hospital Universitario Son Dureta Recruiting
Palma de Mallorca, Baleares, Spain, 07014
Contact: Javier Piérola, Biologist    0034666149639   
Principal Investigator: Javier Piérola, Biologist         
Sponsors and Collaborators
Sociedad Española de Neumología y Cirugía Torácica
Spanish Research Center for Respiratory Diseases

Responsible Party: Javier Piérola Lopetegui, Hospital Universitario Son Dureta Identifier: NCT01141829     History of Changes
Other Study ID Numbers: NADPHPM2010
First Posted: June 11, 2010    Key Record Dates
Last Update Posted: June 11, 2010
Last Verified: January 2010

Keywords provided by Sociedad Española de Neumología y Cirugía Torácica:
NADPH oxidase

Additional relevant MeSH terms:
Sleep Apnea Syndromes
Sleep Apnea, Obstructive
Pathologic Processes
Respiration Disorders
Respiratory Tract Diseases
Signs and Symptoms, Respiratory
Signs and Symptoms
Sleep Disorders, Intrinsic
Sleep Wake Disorders
Nervous System Diseases