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Swedish Mammography Cohort (SMC)

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ClinicalTrials.gov Identifier: NCT01127698
Recruitment Status : Completed
First Posted : May 21, 2010
Last Update Posted : February 28, 2014
Sponsor:
Collaborator:
Harvard School of Public Health
Information provided by (Responsible Party):
Alicja Wolk, Karolinska Institutet

Brief Summary:
The Swedish Mammography Cohort began in 1987-1990, when 66,651 women living in two counties in central Sweden completed a mailed questionnaire that included items about their diet, parity, age at first child's birth, history of breast cancer in family, weight, height, and education. Follow-up questionnaires have been sent out in 1997 and in 2008-09.

Condition or disease
Cancers Cardiovascular Diseases Cataract Gastrointestinal Diseases Osteoporosis Fractures

Detailed Description:

From 1987 to 1990 a population-based mammography screening program was introduced in two counties in central Sweden. In Västmanland County all women born between 1917 and 1948 received a mailed invitation to be screened by mammography between March 1987 and March 1989 (n=41,786) together with a 6-page questionnaire; 31,735 women (76%) returned the completed questionnaires. In Uppsala County all women born between 1914 and 1948 were invited to the screening and received the same questionnaire between January 1988 and December 1990 (n=48517); 34916 women (72%) returned the completed questionnaires. Hence, questionnaires completed before undergoing mammography were obtained from 66,651 women (74%) in the source population. These questionnaires included items about diet, parity, age at first child's birth, history of breast cancer in family, weight, height, and education.

In 1997 a second questionnaire was sent to all cohort members who were still living in the study area. The questionnaire updated information about diet and was extended to include information on physical activity, medical history, age at menarche, history of oral contraceptive use, age at menopause, postmenopausal hormone use and lifestyle factors such as cigarette smoking history and use of dietary supplements. Majority of questions in the questionnaires have been validated.

During 2008-09, the exposure information was updated and extended by sending out two new questionnaires - one questionnaire on health including several signs of symptoms, sleeping, social relations etc (2008) and one on diet, dietary supplement use, and lifestyle factors (2009).

Incident cases of cancer are ascertained by record linkages of the study population with the National Swedish Cancer Register and the Regional Cancer Registers. Cardiovascular and other diseases as well as surgeries and causes of death are identified by linkage to the National Inpatient and other registries at the Swedish Board of Health and Welfare. Ascertainment of cancer cases and other diseases is almost 100% complete. Dates of deaths are ascertained through the Swedish Death Register (100% complete), and information on date of moving out of the study area is obtained by linkage with the Swedish Population Register.


Study Type : Observational
Estimated Enrollment : 61433 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Swedish Mammography Cohort
Study Start Date : March 1987
Actual Primary Completion Date : December 1990

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Mammography
U.S. FDA Resources




Primary Outcome Measures :
  1. Breast cancer [ Time Frame: 1987-2010 ]
  2. Colorectal cancer [ Time Frame: 1987-2010 ]
  3. Endometrial Cancer [ Time Frame: 1987-2010 ]
  4. Ovarian cancer [ Time Frame: 1987-2010 ]
  5. Pancreatic cancer [ Time Frame: 1987-2010 ]
  6. Stomach cancer [ Time Frame: 1987-2010 ]
  7. Kidney cancer [ Time Frame: 1987-2010 ]
  8. Bladder cancer [ Time Frame: 1987-2010 ]
  9. Cardiovascular diseases [ Time Frame: 1987-2010 ]
  10. Mortality [ Time Frame: 1987-2010 ]
  11. Cataract [ Time Frame: 1987-2010 ]
  12. Fractures, hip fractures [ Time Frame: 1987-2014 ]

Biospecimen Retention:   Samples With DNA
Saliva Blood


Information from the National Library of Medicine

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Ages Eligible for Study:   40 Years to 74 Years   (Adult, Senior)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Women born between 1914 and 1948, living in central Sweden (Uppsala and Västmanlands counties)
Criteria

Inclusion Criteria:

  • All women born between 1914 and 1948, living in central Sweden

Exclusion Criteria:


Additional Information:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Responsible Party: Alicja Wolk, Professor, Karolinska Institutet
ClinicalTrials.gov Identifier: NCT01127698     History of Changes
Other Study ID Numbers: 1706/2010-631-1
First Posted: May 21, 2010    Key Record Dates
Last Update Posted: February 28, 2014
Last Verified: February 2014

Additional relevant MeSH terms:
Cardiovascular Diseases
Osteoporosis
Cataract
Gastrointestinal Diseases
Digestive System Diseases
Bone Diseases, Metabolic
Bone Diseases
Musculoskeletal Diseases
Metabolic Diseases
Lens Diseases
Eye Diseases