Respiratory Quotient and Food Liking, Food Wanting and Food Consumption

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01122082
Recruitment Status : Completed
First Posted : May 12, 2010
Last Update Posted : August 24, 2017
Centre National de la Recherche Scientifique, France
Information provided by (Responsible Party):
Laurent BRONDEL, University of Burgundy

Brief Summary:

The purpose of this study is to observe the influence of carbohydrate-to-fat balance on liking, wanting and food consumption in humans.

16 normal-weight men (age: 23 ± 3 y)had completed a randomized 4-condition crossover study. The sessions differed by the composition of the breakfast which was rich in carbohydrates (HCB), low in carbohydrates (LCB), rich in fat (HFB) and low in fat (LFB). The HCB and HFB contained 2072 kJ, while the LCB and LFB contained 565 kJ. Two hours and 20 min later, energy expenditure (EE) and respiratory quotient (RQ) were measured before olfactory liking for 4 foods items and then ad libitum energy intake (EI) during a snack (sweet and fatty toast) were evaluated.

Condition or disease Intervention/treatment Phase
Obesity Behavioral: food preloads Not Applicable

Detailed Description:
In accordance with the carbohydrate-based models of feeding, one may expect that food choices as well as "liking" and "wanting" (the two components of the reward system) could be influenced by glycogen stores and the carbohydrate-to-fat balance. More precisely, one may expect that a high fat oxidation rate could increase liking and wanting carbohydrates to replenish glycogen stores and conversely, that a high carbohydrate oxidation rate could produce the reverse. In order to validate this hypothesis, the present study has been conducted to investigate in humans the influence of the carbohydrate-to-fat oxidation ratio on carbohydrate-to-fat selection and the food reward system.

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 16 participants
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single (Participant)
Primary Purpose: Basic Science
Official Title: Influence of Respiratory Quotient on Food Liking, Food Wanting, Macronutrient Selection and Food Consumption in Humans
Study Start Date : October 2008
Actual Primary Completion Date : August 2009
Actual Study Completion Date : January 2010

Intervention Details:
    Behavioral: food preloads
    Subjects will eat in the morning during breakfast 300g cottage cheese (627kJ - 147kcal; 13.2g carbohydrate, 0.3g fat, 23g protein) plus, according to the situations, either: 90g sucrose, HCB); 6g aspartame; 40g vegetable oil; 40g paraffin oil. Therefore two breakfast will have the same energy content (2072kJ - 495kcal), as did the other two(565 kJ - 135kcal).
    Other Names:
    • food intake
    • metabolism

Primary Outcome Measures :
  1. Respiratory quotient [ Time Frame: 6 months ]
    Respiratory quotient is the ratio of CO2 production on oxygen consumption measured in the expiratory flow

Secondary Outcome Measures :
  1. food liking [ Time Frame: 6 months ]
    Food liking is the preference for 4 food items smelt

  2. food wanting [ Time Frame: 6 months ]
    food wanting is the selection of 4 kind of toasts during a snack

  3. food consumption [ Time Frame: 6 months ]
    is the amount of food eaten during the snack

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Good health
  • Absence of medication
  • Moderate physical activity (irregular and less than 5 h/wk)
  • Low-smoking habit (less than 5 cigarettes/d)
  • Normal body mass index (20< BMI <25)

Exclusion Criteria:

  • Eating disorders
  • Dieting or fasting
  • Aversions for the foods offered and elevated 'cognitive restriction of eating' (score ≥ 7) according to the Three Factor Eating Questionnaire

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01122082

Centre des Sciences du Goût et de l'Alimentation
Dijon, France, 21000
Sponsors and Collaborators
University of Burgundy
Centre National de la Recherche Scientifique, France
Study Director: Luc Penicaud, MD Centre National de la Recherche Scientifique, France

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Laurent BRONDEL, Professor, University of Burgundy Identifier: NCT01122082     History of Changes
Other Study ID Numbers: ABC123
CSGA-AA1234-01 ( Registry Identifier: 02052009 )
First Posted: May 12, 2010    Key Record Dates
Last Update Posted: August 24, 2017
Last Verified: August 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Keywords provided by Laurent BRONDEL, University of Burgundy:
energy intake
energy expenditure
macronutrient selection