Marinol in Trichotillomania or Obsessive Compulsive Disorder
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|ClinicalTrials.gov Identifier: NCT01093976|
Recruitment Status : Completed
First Posted : March 26, 2010
Results First Posted : September 27, 2013
Last Update Posted : September 27, 2013
|Condition or disease||Intervention/treatment||Phase|
|Trichotillomania Obsessive Compulsive Disorder||Drug: Dronabinol||Phase 2|
The study consists of twelve weeks of open-label dronabinol. All eligible study subjects will be started on open-label dronabinol 2.5mg/day for 3 weeks. The dose will be increased to 5mg/day at visit 2 (Week 3), to10mg/day at visit 3 (Week 6), and to 15mg/day at Visit 4 (Week 9) unless clinical improvement is attained at a lower dose (clinical improvement will be assessed by the investigator with respect to obsessive thoughts, urges and compulsive behaviors). Subjects will be seen every three weeks during the 12-week, open-label study. All efficacy and safety assessments will be performed at each visit. Subjects who are not compliant with their use of study medication (i.e. failing to take medication for three or more consecutive days) will be discontinued from the study.
Laboratory testing, including liver function tests, a blood chemistry panel, and urine toxicology will be completed for subjects at baseline if in the opinion of the study physician the medical history of the subject warrants such tests for their safety. All females, regardless of age, will undergo a urine pregnancy test at screening and all subjects will be required to do a urine drug screen at the screening visit to test for drugs of abuse.
At study conclusion, subjects will be given the option to continue on medication (via prescription) if covered by insurance, and will then be followed in our clinic or referred to another psychiatrist. All study subjects will be offered follow-up care with CBT and/or medication in our outpatient clinic (if covered by insurance) or be given a list of appropriate referrals in the community.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||14 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||An Open-Label Study of Dronabinol, a Cannabinoid Agonist, for Obsessive Compulsive Disorder and the Obsessive-Compulsive Spectrum Disorders Trichotillomania and Pathological Skin Picking|
|Study Start Date :||April 2010|
|Actual Primary Completion Date :||January 2011|
|Actual Study Completion Date :||February 2011|
Dronabinol (Marinol) - 2.5mg-15mg by mouth once a day for twelve-weeks
2.5mg-15mg by mouth once a day for twelve-weeks
Other Name: MARINOL
- Massachusetts General Hospital Hairpulling Scale (MGH-HPS) Total Score [ Time Frame: Subjects were followed for their duration of participation in the study (12-weeks) ]The MGH-HPS is a 7-item, self-report scale that rates urges to pull hair, actual amount of pulling, perceived control over behavior, and distress associated with hair pulling over the past seven days. Total possible score is a 28 indicating the highest level of severity out of a scale from 0-28.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01093976
|United States, Minnesota|
|Ambulatory Research Center|
|Minneapolis, Minnesota, United States, 55454|
|Principal Investigator:||Jon E Grant, JD, MD, MPH||University of Minnesota - Clinical and Translational Science Institute|