Effect of Colostrum on Gut Permeability and Endotoxin Level in Chronic Alcoholic Disease
|ClinicalTrials.gov Identifier: NCT01088087|
Recruitment Status : Unknown
Verified November 2009 by Gangnam Severance Hospital.
Recruitment status was: Recruiting
First Posted : March 17, 2010
Last Update Posted : March 17, 2010
Chronic alcohol ingestion is related with leaky gut syndrome. Colostrum is well-studied that it has a effect of decreasing the degree of leaky gut syndrome.
So the investigators are planning to find out whether Colostrum has a effect of decreasing the degree of leaky gut syndrome.
|Condition or disease||Intervention/treatment||Phase|
|Leaky Gut Syndrome||Dietary Supplement: colostrum||Phase 2 Phase 3|
We randomly sort the participant as placebo group and colostrum group. Each group consists of 17 people. and the duration of our study for one participant is 3 weeks. (Participant takes colostrum for 3 weeks.)
When a person gets leaky gut syndrome, his or her endotoxin and lactulose/mannitol ratio (L/M ratio, in urine) can elevate.
So We will compare the value of those two parameters and LFT. etc. after the administration of colostrum or placebo.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||34 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Double (Participant, Investigator)|
|Official Title:||Effect of Colostrum Administration on Improving Gut Permeability and Serum Endotoxin Level in Chronic Alcohol Drinkers With Hepatic Dysfunction|
|Study Start Date :||March 2010|
|Estimated Primary Completion Date :||September 2010|
|Estimated Study Completion Date :||December 2010|
|Placebo Comparator: Colostrum||
Dietary Supplement: colostrum
colostrum, 2g, 2 times a day, for 3 weeks
Other Name: Mucoba
|No Intervention: Sugar pill|
- endotoxin [ Time Frame: 1st visit and 3 weeks after 1st visit ]
- lactulose/mannitol ratio [ Time Frame: 3 weeks ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01088087
|Contact: Jae Yong Shim, Masterfirstname.lastname@example.org|
|Contact: Hong Bae Kim, Bachelor||82-02-584-2823|
|Korea, Republic of|
|Gangnam Severance Hospital : Family medicine department||Recruiting|
|Seoul, Korea, Republic of|
|Contact: Jae Yong Shim, Master 82-02-2019-3155 email@example.com|
|Contact: Hong Bae Kim, Bachelor 82-02-584-2823|
|Sub-Investigator: Hong Bae Kim, Bacholer|
|Study Director:||Jae Yong Shim, Master||Gangnam Severance Hospital|