Impact of Spices and Herbs on Endothelial Function
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT01085019|
Recruitment Status : Completed
First Posted : March 11, 2010
Last Update Posted : June 28, 2012
|Condition or disease||Intervention/treatment||Phase|
|Endothelial Function||Dietary Supplement: Cinnamon Dietary Supplement: Oregano Dietary Supplement: Ginger Dietary Supplement: Rosemary Dietary Supplement: Black pepper Dietary Supplement: Placebo||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||224 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Double (Participant, Care Provider)|
|Official Title:||Investigation of the Impact of Spices and Herbs on Endothelial Function and Other CVD Risk Factors in Men and Women.|
|Study Start Date :||March 2010|
|Actual Primary Completion Date :||June 2011|
|Actual Study Completion Date :||December 2011|
|Experimental: Dietary supplement: Cinnamon||
Dietary Supplement: Cinnamon
2.8g/day of cinnamon in capsules during 4 weeks.
|Experimental: Dietary supplement: Oregano||
Dietary Supplement: Oregano
2.8g/day of oregano in capsules during 4 weeks.
|Experimental: Dietary supplement: Ginger||
Dietary Supplement: Ginger
2.8g/day of ginger in capsules during 4 weeks.
|Experimental: Dietary supplement: Rosemary||
Dietary Supplement: Rosemary
2.8g/day of rosemary in capsules during 4 weeks.
|Experimental: Dietary supplement: Black pepper||
Dietary Supplement: Black pepper
2.8g/day of black pepper in capsules for 4 weeks.
|Placebo Comparator: Dietary supplement: Placebo||
Dietary Supplement: Placebo
2.8 g/day of placebo in capsules (corn starch) during 4 weeks.
- Endothelial function measured by endopat system (the endothelium-mediated changes in vacular tone) [ Time Frame: at week 0 and week 4 ]
- Circulating level of plasma lipoproteins-lipids [ Time Frame: at week 0 and week 4 ]
- Oxidative stress [ Time Frame: at week 0 and week 4 ]
- Endothelial activation and inflammatory markers [ Time Frame: at week 0 and week 4 ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01085019
|Richardson Centre of Functional Foods and Nutracuticals|
|Winnipeg, Manitoba, Canada, R3T 6C5|
|Institute of Nutraceuticals and Functional Foods|
|Quebec City, Quebec, Canada, G1V 0A6|
|Principal Investigator:||Charles Couillard, Ph.D||Laval University|