Risk Factors and Biomarkers Associated With Recurrence After Excision of Primary Pterygium
|ClinicalTrials.gov Identifier: NCT01068496|
Recruitment Status : Terminated (Other and future studies on lipiview in pterygium will cover this current trial sufficiently.)
First Posted : February 15, 2010
Last Update Posted : May 20, 2015
|Condition or disease|
A comprehensive questionnaire will be used to evaluate the environmental, biological, physical and behavioral risk factors of associated with the recurrence after pterygium excision.
Slit lamp digital color photographs will be taken on primary and recurrent pterygium and pterygium will be graded in three levels of severity, based on relative transparency of pterygium tissue; grade 1 (transparent), grade 2 (intermediate), and grade 3 (opaque) to see whether the risk factors correlate to the morphology of the pterygium.
Tear samples will be collected before surgery using schirmers strip.Proteins in tear samples will be analyzed using the iTRAQ method.
The transcriptional differences in pterygium and conjunctival tissue samples will be analyzed using western blot, qPCR and immunohistochemistry assays.
|Study Type :||Observational|
|Actual Enrollment :||1 participants|
|Official Title:||Risk Factors and Biomarkers Associated With Recurrence After Excision of Primary Pterygium|
|Study Start Date :||March 2010|
|Actual Primary Completion Date :||December 2014|
|Actual Study Completion Date :||December 2014|
- biomarkers [ Time Frame: 12 months ]
Elevation of biomarkers in pterygium tissue and tears (transcripts, proteins, or tear proteins) at the time of initial presentation of primary pterygium may predict the post-surgical recurrence within one year.
visits: 2 further visits at 6 months and 12 months after surgery
Biospecimen Retention: Samples With DNA
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01068496
|Singapore National Eye Centre|
|Singapore, Singapore, 168571|
|Singapore National Eye Center|
|Singapore, Singapore, 168751|
|Study Chair:||Samanthila Waduthantri||Singapore National Eye Centre|
|Study Chair:||Laurence Lim, MBBS||Singapore National Eye Centre|
|Study Chair:||Federico Luengo Gimeno||Singapore National Eye Centre|
|Study Chair:||Jodhbir Mehta||Singapore National Eye Centre|