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The Diagnosis of Chronic Pancreatitis

This study is currently recruiting participants. (see Contacts and Locations)
Verified August 2016 by Haukeland University Hospital
University of Bergen
Information provided by (Responsible Party):
Georg Gjorgji Dimcevski, Haukeland University Hospital Identifier:
First received: January 29, 2010
Last updated: August 17, 2016
Last verified: August 2016

To develop a new standardized multimodal diagnostic approach to CP considering:

WP 1: Fat in faeces and functional testing; the combination of tests has to be easy to practice, should take as little time as possible and discomfort for the patient has to be minimized WP 2: Advanced ultrasonography and imaging modalities. The focus is on validating standard parenchymal, contrast enhanced and functional ultrasound compared to a modern imaging standard. (CT, EUS, MRI)

To evaluate the reliability and feasibility of these novel methods in healthy volunteers; AND

To compare findings in known severe CP patients and different stages of pancreatic insufficiency in patients with CP.

Condition Intervention
Chronic Pancreatitis
Other: diagnostic test

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: A Multimodal Approach to Diagnose Patients With Chronic Pancreatitis

Resource links provided by NLM:

Further study details as provided by Haukeland University Hospital:

Primary Outcome Measures:
  • Development of pancreatic insufficiency [ Time Frame: 5 years ]
  • Peak enzyme Concentration IE [ Time Frame: 5 Years ]

Secondary Outcome Measures:
  • development of diabetes [ Time Frame: 5 years ]
  • Development of pain [ Time Frame: 5 years ]
  • weight loss [ Time Frame: 5 years ]
  • peak amylase [ Time Frame: 5 Years ]

Other Outcome Measures:
  • lipase peak IE [ Time Frame: 5 Years ]
  • Classical score US [ Time Frame: 5 Years ]
  • Rosemont score US [ Time Frame: 5 Years ]

Biospecimen Retention:   Samples With DNA
Pankreatic juice Duodenal tissue Blood

Estimated Enrollment: 100
Study Start Date: August 2009
Estimated Study Completion Date: August 2020
Estimated Primary Completion Date: August 2020 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Patients with suspected Chronic Pancreatitis
Other: diagnostic test
Control group
Healthy controls
Other: diagnostic test

  Show Detailed Description


Ages Eligible for Study:   16 Years to 90 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Patient with suspected chronic pancreatitis age 18-67 years

Inclusion Criteria:

  • The patients will be included from the Department of Medicine at Haukeland University Hospital in Norway. The Marseille-Rome diagnostic criteria will be used. Patients will be scored according to the Layer score. The symptoms should be unrelated to other systemic diseases.

Exclusion Criteria:

  • Personality disturbances and alcohol consumption 24 hours prior to the study. Any other diseases and drugs associated with malabsorption; pregnancy or lactating women; heart disease or allergy against MR or ultrasound contrast agents.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01059669

Contact: Georg Dimcevski, M.D 55972903
Contact: Gilja Odd Helge, Professor 55975000

Haukeland University Hospital Recruiting
Bergen, Norway, 5021
Contact: Georg Dimcevski    55972903   
Principal Investigator: Georg Dimcevski, MD         
Sponsors and Collaborators
Haukeland University Hospital
University of Bergen
Principal Investigator: Georg Dimcevski, PhD Haukeland University Hospital
  More Information

Responsible Party: Georg Gjorgji Dimcevski, MD, Haukeland University Hospital Identifier: NCT01059669     History of Changes
Other Study ID Numbers: REK nr 241.08
Study First Received: January 29, 2010
Last Updated: August 17, 2016

Keywords provided by Haukeland University Hospital:
Chronic pancreatitis
Exocrine insufficiency

Additional relevant MeSH terms:
Pancreatitis, Chronic
Pancreatic Diseases
Digestive System Diseases processed this record on April 24, 2017