Effects of Physical Training on Bone and Muscle Quality, Muscle Strength, and Motor Coordination in Children With NF1
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ClinicalTrials.gov Identifier: NCT01058330 |
Recruitment Status :
Completed
First Posted : January 28, 2010
Last Update Posted : November 19, 2014
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Condition or disease | Intervention/treatment | Phase |
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Neurofibromatosis Type 1 | Other: Plyometric training program | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 35 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Prevention |
Official Title: | Effects of Physical Training on Bone and Muscle Quality, Muscle Strength, and Motor Coordination in Children With Neurofibromatosis Type 1 |
Study Start Date : | February 2010 |
Actual Primary Completion Date : | February 2014 |
Actual Study Completion Date : | February 2014 |

Arm | Intervention/treatment |
---|---|
Active Comparator: Plyometric physical training
Individualized plyometric training program to increase strength, coordination, and bone density.
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Other: Plyometric training program
The intervention is a year long individualized plyometric exercise training program. Examples of plyometric activities include jumping, hopping, running, and throwing. The number of plyometric exercises will increase gradually to prevent over training to a total of 5 lower extremity exercises and 5 upper extremity exercises |
No Intervention: Control Group
This group will have no intervention
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- Bone & muscle quality, DXA, pQCT, & bone ultrasound. [ Time Frame: 1 year ]
- Motor proficiency BOT-2. Muscle strength force plate & dynamometer. Quality of life questionnaires. [ Time Frame: 1 year ]

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Ages Eligible for Study: | 4 Years to 19 Years (Child, Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Fulfill NIH clinical diagnostic criteria
Exclusion Criteria:
- Visual impairment
- Participation in a simultaneous medical intervention trial
- Orthopedic procedure within the last 6 months.
- Pregnancy
- Home location greater than 3-4 hours drive time from Shriners Hospital
- Tibial pseudarthrosis

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01058330
United States, Utah | |
Shriners Hospitals for Children, Salt Lake City | |
Salt Lake City, Utah, United States, 84103 | |
University of Utah | |
Salt Lake City, Utah, United States, 84132 |
Principal Investigator: | David Stevenson, MD | Shriners Hospitals for Children |
Responsible Party: | David Stevenson, MD, Assistant Professor, Division of Medical Genetics, University of Utah, Shriners Hospitals for Children |
ClinicalTrials.gov Identifier: | NCT01058330 History of Changes |
Other Study ID Numbers: |
SLC00038711 |
First Posted: | January 28, 2010 Key Record Dates |
Last Update Posted: | November 19, 2014 |
Last Verified: | November 2014 |
Keywords provided by David Stevenson, MD, Shriners Hospitals for Children:
Neurofibromatosis type 1 NF1 |
Additional relevant MeSH terms:
Neurofibromatoses Neurofibromatosis 1 Neurofibroma Nerve Sheath Neoplasms Neoplasms, Nerve Tissue Neoplasms by Histologic Type Neoplasms Neoplastic Syndromes, Hereditary Neurocutaneous Syndromes |
Nervous System Diseases Heredodegenerative Disorders, Nervous System Neurodegenerative Diseases Genetic Diseases, Inborn Peripheral Nervous System Diseases Neuromuscular Diseases Peripheral Nervous System Neoplasms Nervous System Neoplasms |